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Table of Contents
Vol. 60, No. 1, 1999
Issue release date: January–February 1999
Section title: Original Paper: Stomach
Digestion 1999;60:34–40
(DOI:10.1159/000007586)

Augmentation of Water-Immersion Stress- Induced Gastric Mucosal Lesions in BALB/c Mice Infected with Helicobacter felis

Matsushima Y. · Kinoshita Y. · Watanabe M. · Hassan S. · Fukui H. · Maekawa T. · Okada A. · Kawanami C. · Kishi K. · Watanabe N. · Nakao M. · Chiba T.
aDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, b2nd Division of Internal Medicine, Shimane, cDepartment of Pathology, Kobe University of Allied Medical Sciences, Kobe, and dPharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd., Osaka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper: Stomach

Published online: 1/18/1999

Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background and Aims: Inoculation of Helicobacter felis into the murine stomach has been reported to induce chronic gastric inflammation and may be a model of Helicobacter pylori-induced chronic gastritis. In this study, to characterize H. felis-induced gastritis, the gastric production of interleukin-1β (IL-1β) and hepatocyte growth factor (HGF) was measured in mice. Methods: Gastric mucosal lesions were induced in H. felis-infected BALB/c mice by water-immersion stress. The severity score of gastric erosions per stomach was measured as the sum of the length of erosions. Gene expression of IL-1β and HGF were analyzed by Northern blot analysis and production of HGF was examined using the enzyme immunoassay method. Results: Water-immersion stress induced gastric mucosal lesions accompanied by increased expression of IL-1β mRNA. H. felis infection evoked enhanced expression of IL-1β and HGF genes. When H. felis-infected mice were stressed by water immersion, the mucosal lesions were more severe than those in non-infected mice. Moreover, IL-1β gene expression as well as HGF production was further increased. Conclusions: Although H. felis inoculation did not cause gastric mucosal erosions by itself, it augmented the stress-induced erosions.


Article / Publication Details

First-Page Preview
Abstract of Original Paper: Stomach

Published online: 1/18/1999

Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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