Journal Mobile Options
Table of Contents
Vol. 208, No. 2, 2004
Issue release date: 2004
Dermatology 2004;208:98–103
(DOI:10.1159/000076480)

Association between Chronic Urticaria and Thyroid Autoimmunity: A Prospective Study Involving 99 Patients

Verneuil L. · Leconte C. · Ballet J.J. · Coffin C. · Laroche D. · Izard J.P. · Reznik Y. · Leroy D.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Background: The association between chronic urticaria and thyroid autoimmunity has been a subject of debate. However, this link was suggested in studies searching thyroid microsomal antibodies (TMA), which are less sensitive and less specific than anti-thyroperoxidase antibodies, moreover these studies did not measure anti-TSH receptor antibodies, nor did they use a control group. As a consequence, the results of these studies are difficult to interpret. Objective: The aim of this study was to determine whether chronic urticaria is statistically associated with thyroid autoimmunity. Methods: In a prospective case-control study, we compared the frequency of thyroid autoantibodies in 45 patients with chronic urticaria and in 30 healthy adult volunteers; we also compared the frequency of chronic urticaria in 32 patients with thyroid diseases with thyroid autoantibodies and in 22 patients with thyroid diseases without thyroid autoantibodies. Thyroid autoantibodies and thyroid hormones were measured in all the subjects; antinuclear antibodies, rheumatoid factors, complement, IgE were assessed and routine laboratory tests were done in patients with chronic urticaria. Fisher’s exact statistics were used to test our hypothesis. Results: The frequency of thyroid autoantibodies was significantly higher in patients with chronic urticaria than in healthy controls (26.7%/3.3%; p < 0.01). All the patients with thyroid autoantibodies had thyroid hormone concentrations within the normal limits. The frequency of chronic urticaria was not significantly different (12.5%/9.1%; p = 0.7) in patients with thyroid diseases with or without thyroid antibodies. The rest of the biological investigations revealed only 1 patient with connective tissue disease. Conclusion: This study shows a significant association between chronic urticaria and thyroid autoimmunity, and that tests to detect thyroid autoantibodies are relevant in patients with chronic urticaria, whereas extensive laboratory tests are not.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Leznoff A: Chronic urticaria. Can Fam Physician 1998;44:2170–2176.
  2. Sharma JK, Miller R: Chronic urticaria: Review of the literature. J Cutan Med Surg 1999;3:221–228.
  3. O’Donnell BF, Lawlor F, Simpson J, Morgan M, Greaves M: The impact of chronic urticaria on the quality of life. Br J Dermatol 1997;136:197–201.
  4. Grattan CE, Sabroe RA, Greaves MW: Chronic urticaria. J Am Acad Dermatol 2002;46:645–657.
  5. Ormerod AD: Urticaria and angioedema. Br Med J 1984;289:903–906.
  6. Leznoff A, Sussman GL: Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: A study of 90 patients. J Allergy Clin Immunol 1989;84:66–71.
  7. Collet E, Petit JM, Lacroix M, Bensa AF, Morvan C, Lambert D: Urticaire chronique et pathologie thyroïdienne auto-immune. Ann Dermatol Vénéréol 1995;122:413–416.
  8. Leznoff A, Josse RG, Denburg J, Dolovich J: Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol 1983;119:636–640.
  9. Turktas I, Gokcora N, Demirsoy S, Cakir N, Onal E: The association of chronic urticaria and angioedema with auto-immune thyroiditis. Int J Dermatol 1997;36:187–190.
  10. Gaig P, Garcia-Ortega P, Enrique E, Richart C: Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity. J Invest Allergol Clin Immunol 2000;10:342–345.
  11. Zauli D, Deleonardi G, Foderaro S, Grassi A, Bortolotti R, Ballardini G, et al: Thyroid autoimmunity in chronic urticaria. Allergy Asthma Proc 2001;22:93–95.
  12. Lanigan S.W, Short P, Moult P: The association of chronic urticaria and thyroid autoimmunity. Clin Exp Dermatol 1987;12:335–338.
  13. Rumbyrt JS, Katz JL, Schocket AL: Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol 1995;96:901–905.
  14. Delèvaux I, André M, Tridon A, Aumaître O: Urticaire chronique et thyroïdite de Hashimoto: à propos de six cas. Rev Méd Interne 2001;22:232–237.
  15. Mullin GE, Eastern JS: Cutaneous signs of thyroid disease. Am Fam Physician 1986;34:93–98.
  16. Lanigan SW, Adams JS, Gilkes JJH, Robinson TWE: Association between urticaria and hypothyroidism. Lancet 1984;i:1476.
  17. Crickx B: Quel bilan faire devant une urticaire chronique de l’adulte? Ann Dermatol Vénéréol 1993;120:652–656.
  18. Guillausseau C, Eyquem A, Vincens M, Laurent MF, Leger AF, Savoie JC: Intérêt de la détection des anticorps antithyroïdiens en pathologie thyroïdienne. Pathol Biol 1985;33:653–658.
  19. Kozel MMA, Mekkes JR, Bossuyt PMM, Bos JD: The effectiveness of a history-based diagnostic approach in chronic urticaria and angioedema. Arch Dermatol 1998;134:1575–1580.
  20. Nürnberg W, Henz BM: Urticarial vasculitis syndrome; in Henz MB, Zuberbier, Grabbe, Monroe E (eds): Urticaria. Berlin, Springer, 1998, pp 115–124.
  21. Mathison DA, Arroyave CM, Bhat KN, Hurewitz DS, Marnell DJ: Hypocomplementemia in chronic idiopathic urticaria. Ann Intern Med 1977;86:534–538.
  22. Small P, Barrett D, Biskin N, Champlin E: Chronic urticaria and angioedema. Clin Allergy 1982;12:131–136.
  23. Passeron T, Bahadoran P, Pugliese P, Lacour JP, Ortonne JP: Lack of hypocomplementemia in chronic urticaria. Arch Dermatol 2000;136:558–559.
  24. Sibbald RG, Cheema AS, Lozinski A, Tarlo S: Chronic urticaria. Evaluation of the role of physical, immunologic and other contributory factors. Int J Dermatol 1991;30:381–386.
  25. Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME: Are autoantibodies present in patients with subacute and chronic urticaria? J Investig Allergol Clin Immunol 2001;11:16–20.
  26. Zauli D, Grassi A, Ballardini G, Contestabile S, Zucchini S, Bianchi FB: Thyroid autoimmunity in chronic urticaria. Implications for therapy. Am J Clin Dermatol 2002;3:525–528.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50