Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. It is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by downregulating the β-catenin levels. Recently, it was demonstrated that Axin also plays an important role in a JNK signaling pathway. Axin utilizes discriminatory domains for its distinct roles in the Wnt pathway and in the Axin/JNK pathway. Here we review the data that show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis.
© 2004 S. Karger AG, Basel
- Axin, biological function
- Axin, identification
- Axin/JNK signaling pathway
- Wnt pathway
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Department of Biochemistry, Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong (China)
Tel. +852 2358 7294, E-Mail email@example.com
Received: August 12, 2003
Accepted after revision: September 5, 2003
Number of Print Pages : 15
Number of Figures : 2, Number of Tables : 1, Number of References : 133
Founded 1992 as ‘Biological Signals’ by S.F. Pang (1992–2001) continued as ‘Biological Signals and Receptors’ (1999–2001)
Vol. 13, No. 3, Year 2004 (Cover Date: May-June 2004)
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