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Vol. 17, No. 4, 2004
Issue release date: June 2004
Dement Geriatr Cogn Disord 2004;17:265–268
(DOI:10.1159/000077151)

Epidemiology of Frontotemporal Lobar Degeneration

Ikeda M. · Ishikawa T. · Tanabe H.
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Abstract

A few epidemiologic studies have dealt with the prevalence of frontotemporal lobar degeneration (FTLD), including Pick’s disease. The aim of this study was to review the epidemiologic studies of FTLD in western countries and to compare them with those in Japan. A community-based study of early-onset dementia in London revealed that 12% of cases with frontotemporal dementia (FTD) fulfilled the Lund-Manchester criteria in contrast to 34% of cases with Alzheimer’s disease (AD) in a sample of 185 cases. The Cambridge Group has recently examined the prevalence of early-onset dementia in a community-based study. Of 108 cases, 15.7% had FTLD and 25% had AD. FTLD included 13 FTD cases, and 2 each with semantic dementia (SD) and nonfluent progressive aphasia (PA). Almost one third of cases with FTLD (29%) had a positive family history. Of our consecutive 330 outpatients with dementia (hospital setting without age limitation), 42 (12.7%) had FTLD and 215 (65.1%) had AD. In our series of patients, 22 FTD, 15 SD and 5 PA cases were identified. There was no family history in all subtypes of FTLD. Epidemiologic studies, both community-based and hospital-based, demonstrate that FTLD is a more common cause of early-onset dementia than previously recognized. Regarding the subtypes of FTLD, in Japan, compared with the data from the UK, FTD is less common, SD may be more common and PA is equally common. The reason for this discrepancy is supposed to be mainly based on the role of heredity.



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References

  1. Wahlund LO, Andersen C, Ostberg P: Standardizing frontotemporal dementia: The problem of polysemy. Arch Neurol 2002;59:1203–1204.
  2. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings JL, Benson DF: Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology 1998;51:1546–1555.
  3. Snowden JS, Neary D, Mann DM: Frontotemporal dementia. Br J Psychiatry 2002;180:140–143.
  4. Bozeat S, Gregory CA, Lambon Ralph MA, Hodges JR: Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2000;69:178–186.
  5. Snowden JS, Bathgate D, Varma A, Blackshaw A, Gibbons ZC, Neary D: Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry 2001;70:323–332.
  6. Shigenobu K, Ikeda M, Fukuhara R, Maki N, Hokoishi K, Nebu A, Yasuoka T, Komori K, Tanabe H: The Stereotypy Rating Inventory for frontotemporal lobar degeneration. Psychiatry Res 2002;110:175–187.
  7. Ikeda M, Brown J, Holland AJ, Fukuhara R, Hodges JR: Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2002;73:371–376.
  8. Tanabe H, Nakagawa Y, Ikeda M, Hashimoto M, Yamada N, Kazui H, Nishikawa T, Okuda J: Selective loss of semantic memory for words; in Ishikawa K, McGaugh JL, Sakata H (eds): Brain Processes and Memory. Amsterdam, Elsevier Science, 1996, pp 141–152.
  9. Ikeda M, Hokoishi K, Maki N, Nebu A, Tachibana N, Komori K, Shigenobu K, Fukuhara R, Tanabe H: Increased prevalence of vascular dementia in Japan: A community-based epidemiological study. Neurology 2001;57:839–844.
  10. Brun A, Englund B, Gustafson L, Passant U, Mann DMA, Neary D, Snowden JS: Consensus statement – Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994;57:416–418.
  11. Harvey RJ, Rossor MN, Skelton-Robinson M, Garralda E: Young onset dementia: Epidemiology, clinical symptom, family burden, support and outcome. 1998. Available at: http://www.dementia.ion.ucl.ac.uk
  12. Ratnavalli E, Brayne C, Dawson K, Hodges JR: The prevalence of frontotemporal dementia. Neurology 2002;58:1615–1621.
  13. Hokoishi K, Ikeda M, Maki N, Nebu A, Shigenobu K, Fukuhara R, Komori K, Tanabe H: Fronto-temporal lobar degeneration: A study in Japan. Dement Geriat Cogn Disord 2001;12:393–399.
  14. Kajitani Y, Nakagawa Y, Ogomori K, Ichimiya A, Kawashima N, Urabe M, Ohyagi Y, Sakae N, Yamazaki T, Kira J, Tashiro N: The establishment of a memory clinic at Kyushu University Hospital – Looking back one year after its establishment (in Japanese). Jap J Geriatr Psychiatry 2002;13:1063–1069.
  15. Imamura T, Hirono N, Hashimoto M, Shimomura T, Tanimukai S, Kazui H, Hanihara T, Mori E: Clinical diagnosis of dementia with Lewy bodies in a Japanese Dementia Registry. Dement Geriatr Cogn Disord 1999;10:210–216.
  16. Snowden JS, Neary D, Mann DMA: Frontotemporal Lobar Degeneration: Frontotemporal Dementia, Progressive Aphasia, Semantic Dementia. New York, Churchill Livingstone, 1996.
  17. Ikeda K: Neuropathological discrepancy between Japanese Pick’s disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group. Neuropathology 2000;20:76–82.
  18. Stevens M, van Duijn CM, Kamphorst W, de Knijff P, Heutink P, van Gool WA, Scheltens P, Ravid R, Oostra BA, Niermeijer MF, van Swieten JC: Familial aggregation in frontotemporal dementia. Neurology. 1998;50:1541–1545.
  19. Gustafson L: Frontal lobe degeneration of non-Alzheimer type. 2. Clinical picture and differential diagnosis. Arch Geront Geriatr 1987;6:209–223.
  20. Isaki K, Kurachi M, Matsubara R, Koizumi T, Kobayashi K, Yamaguchi N: Pick’s disease in two brothers (in Japanese). Seishin Shinkeigaku Zasshi 1982;84:594–607.
  21. Iijima M, Tabira T, Poorkaj P, Schellenberg GD, Trojanowski JQ, Lee VM, Schmidt ML, Takahashi K, Nabika T, Matsumoto T, Yamashita Y, Yoshioka S, Ishino H: A distinct familial presenile dementia with a novel missense in the tau gene. Neuroreport 1999;10:497–501.
  22. Yasuda M, Takamatsu J, D’Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 2000;47:422–429.
  23. Tanabe H, Ikeda M, Komori K: Behavioral symptomatology and care of patients with frontotemporal lobe degeneration: Based on the aspects of the phylogenetic and ontogenetic processes. Dement Geriatr Cogn Disord 1999;10(suppl 1):50–54.


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