Vol. 38, No. 3, 2004
Issue release date: May–June 2004
Caries Res 2004;38:258–262
(DOI:10.1159/000077764)
Paper
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Systemic versus Topical Fluoride

Hellwig E. · Lennon Á.M.
aDepartment of Operative Dentistry and Periodontology, Dental Clinic and Dental School, Albert Ludwigs University Freiburg, Freiburg, and bDepartment of Operative Dentistry, Preventive Dentistry and Periodontology, University of Göttingen, Göttingen, Germany
email Corresponding Author


 goto top of outline Key Words

  • Caries prevention
  • Posteruptive fluoride
  • Pre-eruptive fluoride
  • Systemic fluoride
  • Topical fluoride

 goto top of outline Abstract

The actual mechanism of fluoride action is still a subject of debate. A dogma has existed for many decades, that fluoride has to be ingested and acts mainly pre-eruptively. However, recent studies concerning the systemic effect of fluoride supplementation concluded that the caries-preventive effect of fluoride is almost exclusively posteruptive. Moreover, epidemiologists have cast doubt on the validity of the ‘old’ studies dealing with fluoride use. The concept of the posteruptive fluoride effect is supported by in vitro and in situ investigations demonstrating that the mode of action of fluoride can be attributed mainly to its influence on de- and remineralization kinetics of dental hard tissues. Therefore, topical fluoride application (e.g. in the form of fluoridated dentifrices) should be encouraged. There are still important questions open that need to be answered despite existing knowledge about the caries-preventive effect of fluoride.

Copyright © 2004 S. Karger AG, Basel


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 goto top of outline Author Contacts

E. Hellwig
Department of Operative Dentistry and Periodontology
University Clinic of Dentistry, Albert Ludwigs University Freiburg
Hugstetter Strasse 55, DE–79106 Freiburg (Germany)
Tel. +49 761 270 4950, Fax +49 761 270 4762, E-Mail hellwig@zmk2.ukl.uni-freiburg.de


 goto top of outline Article Information

Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 0, Number of References : 40


 goto top of outline Publication Details

Caries Research (Journal of the European Organization for Caries Research (ORCA))
Journal founded 1967 by Y. Ericsson; edited 1970–1987 by K.G. König; 1987–1994 by J.M. ten Cate; 1994–2000 by J. Tenovuo

Vol. 38, No. 3, Year 2004 (Cover Date: May-June 2004)

Journal Editor: R.P. Shellis, Bristol
ISSN: 0008–6568 (print), 1421–976X (Online)

For additional information: http://www.karger.com/journals/cre


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