The actual mechanism of fluoride action is still a subject of debate. A dogma has existed for many decades, that fluoride has to be ingested and acts mainly pre-eruptively. However, recent studies concerning the systemic effect of fluoride supplementation concluded that the caries-preventive effect of fluoride is almost exclusively posteruptive. Moreover, epidemiologists have cast doubt on the validity of the ‘old’ studies dealing with fluoride use. The concept of the posteruptive fluoride effect is supported by in vitro and in situ investigations demonstrating that the mode of action of fluoride can be attributed mainly to its influence on de- and remineralization kinetics of dental hard tissues. Therefore, topical fluoride application (e.g. in the form of fluoridated dentifrices) should be encouraged. There are still important questions open that need to be answered despite existing knowledge about the caries-preventive effect of fluoride.
© 2004 S. Karger AG, Basel
- Caries prevention
- Posteruptive fluoride
- Pre-eruptive fluoride
- Systemic fluoride
- Topical fluoride
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Department of Operative Dentistry and Periodontology
University Clinic of Dentistry, Albert Ludwigs University Freiburg
Hugstetter Strasse 55, DE–79106 Freiburg (Germany)
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Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 0, Number of References : 40
Caries Research (Journal of the European Organization for Caries Research (ORCA))
Journal founded 1967 by Y. Ericsson; edited 1970–1987 by K.G. König; 1987–1994 by J.M. ten Cate; 1994–2000 by J. Tenovuo
Vol. 38, No. 3, Year 2004 (Cover Date: May-June 2004)
Journal Editor: R.P. Shellis, Bristol
ISSN: 0008–6568 (print), 1421–976X (Online)
For additional information: http://www.karger.com/journals/cre
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