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Table of Contents
Vol. 19, No. 4, 2004
Issue release date: July–August 2004
Section title: Paper
Fetal Diagn Ther 2004;19:342–347
(DOI:10.1159/000077963)

Dandy-Walker Malformation: A Review of 78 Cases Diagnosed by Prenatal Sonography

Has R. · Ermiş H. · Yüksel A. · Ibrahimoğlu L. · Yildirim A. · Sezer H.D. · Başaran S.
Departments of aObstetrics and Gynecology and bGenetics, University of Istanbul, Faculty of Medicine, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 1/21/2003
Accepted: 7/22/2003
Published online: 6/16/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: The purpose of this study was to determine the associated abnormalities and clinical outcomes of fetuses with Dandy-Walker malformations. Methods: Sonograms and medical reports of 78 cases were reviewed and information regarding each outcome was collected from autopsy records, hospital charts and specialists caring for the surviving infants. Results: We identified 64 fetuses with classic Dandy-Walker malformation (DW) and 14 fetuses with Dandy-Walker variant (DWV). A high proportion (44.8%) of the parents were consanguineous. The spectrum and proportion of central nervous system (67.1 vs. 71.4%; p = 1.0) and other malformations (43.7 vs. 64.2%; p = 0.57) associated with DW and DWV were similar. Chromosome abnormalities were found in 9 of the 51 (17.6%) fetuses that underwent karyotype analysis. Only 4 of 64 (6.2%) DW and 3 of 14 (21.4%) DWV infants survived (p 0.14), and all surviving infants with DW or DWV had neurological disorders. Conclusions: DW and DWV cases show so many similarities that a clear-cut distinction is difficult. There was no significant difference in the spectrum of associated anomalies and postnatal prognosis between DW and DWV cases.


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 1/21/2003
Accepted: 7/22/2003
Published online: 6/16/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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