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Dandy-Walker Malformation: A Review of 78 Cases Diagnosed by Prenatal Sonography

Has R.a · Ermiş H.a · Yüksel A.a · Ibrahimoğlu L.a · Yildirim A.a · Sezer H.D.a · Başaran S.b
Departments of aObstetrics and Gynecology and bGenetics, University of Istanbul, Faculty of Medicine, Istanbul, Turkey Fetal Diagn Ther 2004;19:342–347 (DOI:10.1159/000077963)

Abstract

Objective: The purpose of this study was to determine the associated abnormalities and clinical outcomes of fetuses with Dandy-Walker malformations. Methods: Sonograms and medical reports of 78 cases were reviewed and information regarding each outcome was collected from autopsy records, hospital charts and specialists caring for the surviving infants. Results: We identified 64 fetuses with classic Dandy-Walker malformation (DW) and 14 fetuses with Dandy-Walker variant (DWV). A high proportion (44.8%) of the parents were consanguineous. The spectrum and proportion of central nervous system (67.1 vs. 71.4%; p = 1.0) and other malformations (43.7 vs. 64.2%; p = 0.57) associated with DW and DWV were similar. Chromosome abnormalities were found in 9 of the 51 (17.6%) fetuses that underwent karyotype analysis. Only 4 of 64 (6.2%) DW and 3 of 14 (21.4%) DWV infants survived (p 0.14), and all surviving infants with DW or DWV had neurological disorders. Conclusions: DW and DWV cases show so many similarities that a clear-cut distinction is difficult. There was no significant difference in the spectrum of associated anomalies and postnatal prognosis between DW and DWV cases.

 

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