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Transferrin Microheterogeneity in Fetal Blood

Wu Y.a · Sakamoto H.a · Kanenishi K.b · Tanaka S.a · Ueno M.a · Hata T.b
Departments of aInflammation Pathology and bPerinatology and Gynecology, Kagawa Medical University, Kagawa, Japan Biol Neonate 2004;86:98–103 (DOI:10.1159/000078311)


Objectives: To investigate the distribution of microheterogeneous subfractions of transferrin in fetal blood and the influence of highly sialylated transferrins on fetal growth. Study Method: Serum transferrin concentrations were determined by a standard turbidimetric assay. Microheterogeneous transferrin subfractions were assessed by crossed immunoisoelectric focusing. Results: In normal term infants, total serum transferrin concentrations and percent distribution of highly sialylated transferrins (≧5-sialo-transferrins) were markedly lower; the percent distributions of hyposialylated transferrins (0- and 1-sialo-transferrins) were apparently higher than those in non-pregnant and pregnant women. There was no significant positive correlation between the serum concentrations of total transferrin or highly sialylated transferrins in infants’ blood and birth weights (r = 0.187, p = 0.582; r = 0.374, p = 0.257, respectively). Conclusion: The transferrin microheterogeneity pattern shifted towards reduced glycosylation and sialylation in addition to a decrease in total transferrin concentration in fetal blood compared to that of non-pregnant and pregnant women. The concentrations of serum total transferrin and the highly sialylated transferrins in fetal blood, if higher than a certain level, did not seem to have any influence on normal fetal growth.


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