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Table of Contents
Vol. 13, No. 4, 2004
Issue release date: July – August
Section title: Original Paper
Open Access Gateway
Med Princ Pract 2004;13:185–190

Selenium in the Treatment of Head and Neck Lymphedema

Bruns F.a,b,f · Büntzel J.c,f · Mücke R.d,f · Schönekaes K.f · Kisters K.e,f · Micke O.b,f
aDepartment of Radiotherapy, Medical School Hannover, Hannover, bDepartment of Radiotherapy, Münster University Hospital, Münster, cDepartment of Otolaryngology, Community Hospital Nordhausen, Nordhausen, dDepartment of Radiotherapy, Community Hospital Weiden, Weiden, and eDepartment of Internal Medicine, St. Anna Hospital Herne, Herne, Germany; fGerman Working Group Trace Elements and Electrolytes in Radiation Oncology (AKTE)
email Corresponding Author

Dr. Oliver Micke

Klinik und Poliklinik für Strahlentherapie-Radioonkologie

Universitätsklinikum Münster, Albert-Schweitzer-Strasse 33

DE–48129 Münster (Germany)

Tel. +49 251 8347839, Fax +49 251 8347355, E-Mail omicke@trace-elements.de


  1. Petrek JA, Pressman PI, Smith RA: Lymphedema: Current issues in research and management. CA Cancer J Clin 2000;50:292–307.
  2. Rockson SG: Lymphedema. Am J Med 2001;110:288–295.
  3. Weissleder H, Schuchardt C: Lymphedema of the arm following breast cancer therapy; in Weissleder H, Schuchardt C (eds): Lymphedema: Diagnosis and Therapy, ed 3. Cologne, Viavital, 2001, pp 187–213.
  4. Weissleder H, Schuchardt C: Iatrogenic alteration of the lymphatic system; in Weissleder H, Schuchardt C (eds): Lymphedema: Diagnosis and Therapy, ed 3. Cologne, Viavital, 2001, pp 156–174.
  5. Paskett ED, Stark N: Lymphedema: Knowledge, Treatment, and Impact among Breast Cancer Survivors. Breast J 2000;6:373–378.
    External Resources
  6. Megens A, Harris SR: Physical therapist management of lymphedema following treatment for breast cancer: A critical review of its effectiveness. Phys Ther 1998;78:1302–1311.
  7. Földi E: The treatment of lymphedema. Cancer 1998;83:2833–2834.
  8. Kasseroller RG, Schrauzer GN: Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: A review. Am J Ther 2000;7:273–279.
  9. Bruns F, Micke O, Bremer M: Current status of selenium and other treatments for secondary lymphedema. J Support Oncol 2003;1:121–138.
  10. Casley-Smith JR: Benzo-pyrones in the treatment of lymphoedema. Int Angiol 1999;18:31–41.
  11. Piller NB: Macrophage and tissue changes in the developmental phases of secondary lymphoedema and during conservative therapy with benzopyrone. Arch Histol Cytol 1990;53:209–218.
    External Resources
  12. Casley-Smith JR, Gaffney RM: Excess plasma proteins as a cause of chronic inflammation and lymphodema: Quantitative electron microscopy. J Pathol 1981;133:243–272.
  13. Casley-Smith JR, Morgan RG, Piller NB: Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. N Engl J Med 1993;329:1158–1163.
  14. Loprinzi CL, Sloan J, Kugler J: Coumarin-induced hepatotoxicity. JCO 1997;15:3167–3168.
  15. Schuchardt C, Pritschow H, Weissleder H: Conservative treatment; in Weissleder H, Schuchardt C (eds): Lymphedema: Diagnosis and Therapy, ed 3. Cologne, Viavital, 2001, pp 336–358.
  16. Schünemann H, Willich N: Lymphoedema of the arm after treatment of cancer of the breast: A study of 5868 cases. Dtsch Med Wochenschr 1997;122:536–541.
  17. Walley DR, Augustine E, Saslow D, Bailey S, Jeffs E, Lasinski B, Plotkin J, Walker M: American Cancer Society Lymphedema Workshop. Workgroup IV: Lymphedema treatment resources-professional education and availability of patient services. Cancer 1998;83:2886–2887.
  18. Rockson SG, Miller LT, Senie R, Brennan MJ, Casley-Smith JR, Földi E, Földi M, Gamble GL, Kasseroller RG, Leduc A, Lerner R, Mortimer PS, Norman SA, Plotkin CL, Rinehart-Ayres ME, Walder AL: American Cancer Society Lymphedema Workshop. Workgroup III: Diagnosis and management of lymphedema. Cancer 1998;83:2882–2885.
  19. Ewald H: Radiotherapy of head and neck tumours and risk of lymphedema (in German). Z Lymphol 1996;20:21–26
  20. Micke O, Bruns F, Schäfer U, Kisters K, Hesselmann S, Willich N: Selenium in the treatment of acute and chronic lymphedema. Trace Elem Electrolytes 2000;17:206–209.
  21. Brenke R, Siems W: Adjuvant therapy in lymphedema. Z Lymphol 1996;20:31–35.
  22. Kasseroller R: Sodium selenite as prophylaxis against erysipelas in secondary lymphedema. Anticancer Res 1998;18:2227–2230.
  23. Beier A, Siems W, Brenke R, Grune T: Increased formation of free radicals in chronic lymphedema. Z Lymphol 1994;18:8–11.
  24. Dietz A, Rudat V, Nollert J, Helbig M, Vanselow B, Weidauer H: Chronic laryngeal edema as a late reaction to radiochemotherapy. HNO 1998;46:731–738.
  25. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH: RTOG Late Effects Working Group. Overview. Late Effects on Normal Tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995;31:1041–1042.
  26. Földi E: Treatment of lymphedema and patient rehabilitation. Anticancer Res 1998;18:2211–2212.
  27. Miller AJ, Bruna J, Beninson J: A universally applicable clinical classification of lymphedema. Angiology 1999;50:189–192.
  28. Herpertz U: Measuring and documentation of edema. Z Lymphol 1994;18:24–30.
  29. Johnson EW: Visual analog scale (VAS). Am J Phys Med Rehabil 2001;80:717.
  30. Obenheimer H, Jankowiak P, Berlemann K, Hermann V, Diethelm A: Clinical and biological effects of selenium in edema; in Gonzalez G (ed): Lymphedema: New Perspectives in Research and Treatment. Zaragossa, 1976.
  31. Peters GM, Herbert WD: Reduction of edema in brain tumors by selenium application. Acta Neurol Pathol Oncol 1957;11:351–353.
  32. Whanger PD: Selenoprotein W: A review. Cell Mol Life Sci 2000;57:1846–1852.
  33. Rayman MP: The importance of selenium to human health. Lancet 2000;356:233–241.
  34. Mücke R, Micke O, Schönekaes KG: Serum selenium levels, glutathione peroxidase activities and serum redox potential levels in patients with untreated non-small cell lung cancer and adenocarcinoma of the rectum. Trace Elem Electrolytes 2003;20:148.
  35. Miller S, Walker SW, Arthur JR, Nicol F, Pickard K, Lewin MH, Howie AF, Beckett GJ: Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin Sci (Lond) 2001;100:543–550.
  36. Bahadur S, Amatya RC, Kacker SK: The enigma of post-radiation oedema and residual or recurrent carcinoma of the larynx and pyriform fossa. J Laryngol Otol 1985;99:763–765.
  37. Horvathova M, Jahnova E, Gazdik F: Effect of selenium supplementation in asthmatic subjects on the expression of endothelial cell adhesion molecules in culture. Biol Trace Elem Res 1999;69:15–26.
  38. Kiremidjian-Schumacher L, Roy M, Glickman R, Schneider K, Rothstein S, Cooper J, Hochster H, Kim M, Newman R: Selenium and immunocompetence in patients with head and neck cancer. Biol Trace Elem Res 2000;73:97–111.