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Vol. 134, No. 1, 2004
Issue release date: May 2004
Int Arch Allergy Immunol 2004;134:79–87

IL-9 in Allergic Inflammation

Hauber H.-P. · Bergeron C. · Hamid Q.
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

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Th2 type cytokines such as interleukin (IL)-4, IL-5, IL-9, and IL-13 are important mediators in allergic inflammation. The present review will focus on the role of IL-9 in allergic inflammation. The structure and genomic architecture of IL-9 and its receptor, the source of IL-9 and its regulation as well as its effects on different cell types will be reviewed. Furthermore, the specific role of IL-9 in allergic diseases and the potential therapeutic approach of blocking IL-9 will be discussed.

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