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Table of Contents
Vol. 209, No. 2, 2004
Issue release date: 2004
Section title: Pharmacology and Treatment
Dermatology 2004;209:126–131
(DOI:10.1159/000079596)

Rapid Clearance of Psoriatic Skin Lesions Induced by Topical Cyclopamine

A Preliminary Proof of Concept Study

Taş S. · Avcı O.
aYasemin Sokak No. 6, Narlıdere, bManavkuyu Mahallesi 244Sokak, 5-1/2, Bornova, İzmir,Turkey

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 10/13/2003
Accepted: 1/31/2004
Published online: 8/19/2004

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: We have earlier found a highly efficient induction of the differentiation of epidermal lineage skin tumors by cyclopamine, a steroidal alkaloid inhibitor of the hedgehog/smoothened signaling, under conditions in which cyclopamine exerted no adverse effect on skin. Objective: We aimed to develop a mechanism-based treatment for psoriasis with cyclopamine. Methods: We subjected psoriatic skin lesions to cyclopamine under conditions similar to those we used for skin tumors and evaluated the responses of lesions clinically and by histopathological/immunohistochemical analyses. Results: All treated lesions in different patients having plaque and guttate forms of psoriasis regressed rapidly. Differentiation of the epidermal cells of lesional skin and disappearances of infiltrating inflammatory cells were evident within a day. Lesions were cleared commonly on days 3–4. Former treatment sites followed up for more than 24 months now show a lack of adverse effects in the long term. Conclusion: An effective treatment for psoriasis is described, consistent with intervention in a proximal/key pathogenic event.


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 10/13/2003
Accepted: 1/31/2004
Published online: 8/19/2004

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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