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Vol. 209, No. 3, 2004
Issue release date: 2004
Dermatology 2004;209:228–229

Speckled Lentiginous Nevus Syndrome: Report of a Further Case

Vente C. · Neumann C. · Bertsch H. · Rupprecht R. · Happle R.
aDepartment of Dermatology, Georg August University, Göttingen, and bDepartment of Dermatology, Philipp University, Marburg, Germany

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A 42-year-old man had a large speckled lentiginous nevus on the left side of his trunk. The involved area was painful when touched and paresthetic. Moreover, the ipsilateral half of his body showed a pronounced hyperhidrosis. This case can be categorized as a typical example of speckled lentiginous nevus syndrome, a recently recognized phenotype characterized by a speckled lentiginous nevus of the papular type and ipsilateral neurological abnormalities in the form of dysesthesia, muscular weakness or hyperhidrosis. Speckled lentiginous nevus syndrome represents a mosaic phenotype. Most likely it originates from loss of heterozygosity occurring in a heterozygous embryo at an early developmental stage.

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    External Resources

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