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Speckled Lentiginous Nevus Syndrome: Report of a Further Case

Vente C.a · Neumann C.a · Bertsch H.a · Rupprecht R.a · Happle R.b
aDepartment of Dermatology, Georg August University, Göttingen, and bDepartment of Dermatology, Philipp University, Marburg, Germany Dermatology 2004;209:228–229 (DOI:10.1159/000079895)


A 42-year-old man had a large speckled lentiginous nevus on the left side of his trunk. The involved area was painful when touched and paresthetic. Moreover, the ipsilateral half of his body showed a pronounced hyperhidrosis. This case can be categorized as a typical example of speckled lentiginous nevus syndrome, a recently recognized phenotype characterized by a speckled lentiginous nevus of the papular type and ipsilateral neurological abnormalities in the form of dysesthesia, muscular weakness or hyperhidrosis. Speckled lentiginous nevus syndrome represents a mosaic phenotype. Most likely it originates from loss of heterozygosity occurring in a heterozygous embryo at an early developmental stage.


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