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Table of Contents
Vol. 66, No. 3, 2004
Issue release date: 2004
ORL 2004;66:155–158
(DOI:10.1159/000079994)

Evidence of Bacterial Biofilms in Human Chronic Sinusitis

Cryer J. · Schipor I. · Perloff J.R. · Palmer J.N.
Division of Rhinology, Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pa., USA

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Abstract

The purpose of this study was to evaluate whether bacterial biofilms exist on the sinus mucosa surfaces of human subjects with recalcitrant chronic sinusitis. Scanning electron microscopy was used to evaluate patients with continued symptoms of chronic sinusitis despite prior appropriate medical and surgical management. Morphologic structures that confirm the presence of bacterial biofilms were identified on the sinus mucosa of patients infected with Pseudomonas aeruginosa, a known biofilm former. The presence of bacterial biofilms may explain the recalcitrant nature of some forms of chronic sinusitis.



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References

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  2. Ehrlich GD, Veeh R, Wang X, Costerton JW, Hayes JD, Hu FZ, Daigle BJ, Ehrlich MD, Post JC: Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA 2002;287:1710–1715.
  3. Costerton JW, Veeh R, Shirtliff M, Pasmore M, Post JC, Ehrlich G: The application of biofilm science to the study and control of chronic bacterial infections. J Clin Invest 2003;112:1466–1477.
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  5. Post JC: Direct evidence of bacterial biofilms in otitis media. Laryngoscope 2001;111:2083–2094.
  6. Costerton JW, Stewart PS, Greenberg EP: Bacterial biofilms: A common cause of persistent infections. Science 1999;284:1318–1322.


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