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Vol. 98, No. 2, 2004
Issue release date: October 2004
Nephron Physiol 2004;98:p43–p47

Osteopontin and Calcium Stone Formation

Kleinman J.G. · Wesson J.A. · Hughes J.
aNephrology Division, Veterans Affairs Medical Center, and Medical College of Wisconsin, Milwaukee, Wisc., USA; bPhagocyte Laboratory, MRC Center for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK

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Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.

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