Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Dietary Folate and the Risk of Depression in Finnish Middle-Aged Men

A Prospective Follow-Up Study

Tolmunen T.a · Hintikka J.a · Ruusunen A.b · Voutilainen S.b · Tanskanen A.a · Valkonen V.-P.b · Viinamäki H.a · Kaplan G.A.e · Salonen J.T.b-d
aDepartment of Psychiatry, bResearch Institute of Public Health and cDepartment of Public Health and General Practice, University of Kuopio, Kuopio, and dInner Savo Health Centre, Suonenjoki, Finland; eDepartment of Epidemiology, Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, Mich., USA Psychother Psychosom 2004;73:334–339 (DOI:10.1159/000080385)


Background: Several cross-sectional studies have focused on the low blood folate levels of depressive patients. Nevertheless, no prospective studies have been published on the association between dietary folate and depression. Methods: We studied the association between dietary folate and cobalamin and receiving a discharge diagnosis of depression in a prospective follow-up setting. Our cohort was recruited between 1984 and 1989 and followed until the end of 2000, and it consisted of 2,313 men aged between 42and 60 years from eastern Finland. Results: The mean intake of folate in the whole cohort was 256 µg/day (SD = 76). Those below the median of energy-adjusted folate intake had higher risk of getting discharge diagnosis of depression (RR 3.04, 95% CI: 1.58, 5.86) during the follow-up period than those who had a folate intake above the median. This excess risk remained significant after adjustment for current socioeconomic status, the baseline HPL depression score, the energy-adjusted daily intake of fibre and vitamin C, and the total fat intake. Conclusions: A low dietary intake of folate may be a risk factor for severe depression. This also indicates that nutrition may have a role in the prevention of depression.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50