Vol. 47, No. 6, 2004
Issue release date: 2004
Intervirology 2004;47:335–341
(DOI:10.1159/000080877)
Original Paper
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Benefit of Lamivudine Therapy and Factors Associated with Clinical Outcome in Spontaneous Severe Acute Exacerbation of Chronic Hepatitis B Virus Infection

Tsubota A.a,b · Arase Y.b · Suzuki Y.b · Suzuki F.b · Hosaka T.b · Akuta N.b · Someya T.b · Kobayashi M.b · Saitoh S.b · Ikeda K.b · Kumada H.b
aInstitute of Clinical Medicine and Research (ICMR), Jikei University School of Medicine, Chiba; bDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan
email Corresponding Author


 goto top of outline Key Words

  • Lamivudine
  • Severe acute exacerbation
  • Chronic hepatitis B virus infection
  • Chronic hepatitis B
  • Severe acute exacerbation
  • Hepatic failure

 goto top of outline Abstract

Objective: During the course of chronic hepatitis B virus (HBV) infection, severe acute exacerbations of the infection often occur spontaneously and follow a fulminating progression to fatal hepatic failure. The aim of this study was to clarify potential factors, including benefit of lamivudine therapy, which could influence clinical course of the serious disease in an area of intermediate HBV endemicity. Methods and Results: Using a database of 3,163 chronically HBV-infected patients, 418 (13.2%) developed acute exacerbation of hepatitis B. Of the 418 patients, 52 (12.4%) spontaneously developed severe acute exacerbation and were included in this study. Of the 52 patients, 23 were treated with lamivudine. In multivariate analyses, fulminating progression to hepatic failure (odds ratio, 15.45; 95% confidence interval, 3.71–64.41; p = 0.0002) was a significantly independent predictor of patient survival. Three variables were independently associated with fulminating development of hepatic failure: presence of cirrhosis (29.06, 1.74–85.56, 0.019, respectively), higher baseline bilirubin level (14.89, 1.31–52.91, 0.029, respectively), and genotype B (22.14, 1.59–29.68, 0.021, respectively). Treatment lacking lamivudine was a significant factor that contributed to shorter survival time, development of hepatic failure, and progression to cirrhosis in univariate analyses (p = 0.014, 0.012 and 0.0030, respectively). Conclusion: In an area of intermediate HBV endemicity, certain proportion of chronic hepatitis B patients could spontaneously develop the serious disease. Factors influencing clinical course of the disease should be identified to improve prognosis and establish more rational and effective therapeutic strategies. Lamivudine therapy could potentially benefit the serious disease, although larger series of patients and longer follow-up periods are needed.

Copyright © 2004 S. Karger AG, Basel


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 goto top of outline Author Contacts

Akihito Tsubota, MD
Institute of Clinical Medicine and Research (ICMR)
Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa
Chiba 277-8567 (Japan)
Tel. +81 47 164 1111, Fax +81 47 166 8638, E-Mail atsubo@jikei.ac.jp


 goto top of outline Article Information

Received: October 20, 2003
Accepted: November 24, 2003
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 32


 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 47, No. 6, Year 2004 (Cover Date: 2004)

Journal Editor: U.G. Liebert, Leipzig
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/int


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