Vol. 19, No. 1, 2005
Issue release date: December 2004
Dement Geriatr Cogn Disord 2005;19:51–56
(DOI:10.1159/000080972)
Original Research Article
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A 12-Month Study of the Efficacy of Rivastigmine in Patients with Advanced Moderate Alzheimer’s Disease

Karaman Y.a · Erdoğan F.a · Köseoğlu E.a · Turan T.b · Ersoy A.Ö.a
Departments of aNeurology and bPsychiatry, Medical Faculty, Erciyes University, Kayseri, Turkey
email Corresponding Author


 goto top of outline Key Words

  • Advanced moderate Alzheimer’s disease
  • Rivastigmine

 goto top of outline Abstract

The efficacy of a centrally active cholinesterase inhibitor, rivastigmine tartrate (ENA 713), in patients with advanced moderate Alzheimer’s disease (AD) was evaluated in a 12-month placebo-controlled study. We aimed to investigate whether there was any evidence for the benefits of rivastigmine in patients with severe disease. These patients were compared with matched controls. In this study, 24 patients with advanced moderate AD received rivastigmine for 12 months. Another 20 patients received placebo. Mean daily doses of rivastigmine in the higher-dose group at 3, 6, 9, and 12 months were 6.1 ± 1.0, 8.3 ± 1.2, 8.9 ± 1.3, and 10.7 ± 1.6 mg/day, respectively. Cognitive abilities were assessed using the 11-item cognitive subscale of the Alzheimer Disease Assessment Scale (ADAS-cog). Forty-five percent of placebo-treated patients declined by at least 4 points on the ADAS-cog. Conversely, only 18.3% of patients treated with rivastigmine declined by 4 or more points. Functional disabilities, as assessed using the Disability Assessment for Dementia Scale, remained significantly superior in rivastigmine-treated patients compared with placebo-treated patients. Patients benefited from high-dose rivastigmine treatment on all outcome measures, including the Mini-Mental State Examination, Progressive Deterioration Scale, as well as the Global Deterioration Scale. Patients receiving rivastigmine for 12 months significantly improved compared with placebo-treated patients (p < 0.001). By 52 weeks, patients originally treated with 6–12 mg/day rivastigmine had a significantly better cognitive function than patients originally treated with placebo. Long-term rivastigmine treatment appeared to be well tolerated in patients with advanced moderate AD and significantly benefits the cognitive and functional symptoms of AD.

Copyright © 2005 S. Karger AG, Basel


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 goto top of outline Author Contacts

Füsun Erdoğan
Erciyes University, Medical Faculty
Neurology Department
TR–38039 Kayseri (Turkey)
Tel. +90 352 4374901, Fax +90 352 4375285, E-Mail ferdogan@erciyes.edu.tr


 goto top of outline Article Information

Accepted: May 3, 2004
Published online: September 21, 2004
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 44


 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 19, No. 1, Year 2005 (Cover Date: Released December 2004)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/dem


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