The ecarin clotting time (ECT) is a meizothrombin generation test that allows for precise quantification of direct thrombin inhibitors. The ECT has demonstrated its usefulness for more than 10 years in biochemical-pharmacological investigations as well as in clinical research and in the clinical routine. It has proved valuable especially as a drug-monitoring method in r-hirudin therapy. This test has been adjusted to clinical requirements by numerous modifications. Following the description of the biochemical background and the measuring principle of the ECT, this article gives a short survey of several modifications of the ECT for both preclinical and clinical use, e.g., for biochemical investigations, as a point-of-care method and for cardiac surgery. Advantages and disadvantages of these methods are discussed.
© 2004 S. Karger AG, Basel
- Ecarin clotting time
- Meizothrombin generation test
- Direct thrombin inhibitor
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Prof. Dr. Götz Nowak
Friedrich Schiller University Jena, Medical Faculty
Research Group ‘Pharmacological Haemostaseology’
Drackendorfer Strasse 1, DE–07747 Jena (Germany)
Tel. +49 3641 932 57 00, Fax +49 3641 932 57 02, E-Mail firstname.lastname@example.org
This review is dedicated to the 80th birthday of Fritz Markwardt
Received: July 26, 2004
Accepted after revision: September 14, 2004
Number of Print Pages : 11
Number of Figures : 11, Number of Tables : 0, Number of References : 18
Pathophysiology of Haemostasis and Thrombosis
Vol. 33, No. 4, Year 2003 (Cover Date: July-August 2003)
Journal Editor: J. Rosing, Maastricht
ISSN: 1424–8832 (print), 1424–8840 (Online)
For additional information: http://www.karger.com/pht
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