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A 52-Week Study of the Efficacy of Rivastigmine in Patients with Mild to Moderately Severe Alzheimer’s Disease

Farlow M.a · Anand R.b · Messina Jr J.b · Hartman R.b · Veach J.b
aDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Ind., and bDepartments of Medical Affairs CNS and Statistics, Novartis Pharmaceuticals Corporation, East Hanover, N.J., USA Eur Neurol 2000;44:236–241 (DOI:10.1159/000008243)


The efficacy of a centrally active cholinesterase inhibitor, rivastigmine tartrate (ENA 713; Exelon®), in patients with mild to moderately severe Alzheimer’s disease was evaluated in a 26-week open-label extension of a 26-week, double-blind, placebo-controlled study. By 52 weeks, patients originally treated with 6–12 mg/day rivastigmine had significantly better cognitive function than patients originally treated with placebo.

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