Aim: The aim of this study was to investigate the prognostic accuracy of different subtypes of mild cognitive impairment (MCI): amnestic MCI, multiple domain MCI, and single non-memory domain MCI, for the development of Alzheimer’s dementia (AD) and vascular dementia (VaD). Patients: Nondemented patients from a memory clinic cohort (n = 118), and a stroke cohort (n = 80, older than 55 years and with a cognitive impairment). Results: ‘Multiple domain MCI’ had the highest sensitivity for both AD (80.8%) and VaD (100%), and ‘amnestic MCI’ had the highest specificity (85.9% for AD, 100% for VaD). The positive predictive value was low for all subtypes (0.0–32.7%), whereas the negative predictive value was high (72.8–100%). Discussion: The subtype ‘multiple domain MCI’ has high sensitivity in identifying people at risk for developing AD or VaD. The predictive accuracy of the MCI subtypes was similar for both AD and VaD.
© 2005 S. Karger AG, Basel
- Mild cognitive impairment
- Predementia stage
- Vascular dementia
- Alzheimer’s dementia
- Diagnostic criteria
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Prof. Dr. F.R.J. Verhey
Department Psychiatry and Neuropsychology
PO Box 5800, NL–6202 MD Maastricht (The Netherlands)
Tel. +31 43 3877537, Fax +31 43 3875444
Accepted: May 23, 2004
Published online: December 9, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 4, Number of References : 29
Dementia and Geriatric Cognitive Disorders
Vol. 19, No. 2-3, Year 2005 (Cover Date: Released February 2005)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem
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