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Vol. 19, No. 2-3, 2005
Issue release date: February 2005
Dement Geriatr Cogn Disord 2005;19:140–144
(DOI:10.1159/000082885)

Autonomic Function Assessed by Heart Rate Variability Is Normal in Alzheimer’s Disease and Vascular Dementia

Allan L.M. · Kerr S.R.J. · Ballard C.G. · Allen J. · Murray A. · McLaren A.T. · Kenny R.A.
aInstitute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, and bRegional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, and cWolfson Centre for Age-Related Disorders, King’s College London, London, UK

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Abstract

Heart rate variability (HRV) is a sensitive method for the assessment of autonomic function and requires little cooperation from the subject, making it suitable for use in dementia. Preliminary studies have suggested that HRV may be impaired in Alzheimer’s disease (AD). HRV has not been studied in vascular dementia (VAD). We investigate autonomic function in AD and VAD, using power spectral analysis of HRV. One hundred and fourteen participants were evaluated (14 AD, 20 VAD and 80 controls). The resting ECG was recorded for 5 min with participants in the supine position. Power spectral analysis used to obtain spectral bands in the very-low-frequency (<0.04 Hz), low-frequency (0.04–0.15 Hz) and high-frequency (0.15–0.40 Hz) bands and total spectral power (<0.40 Hz) according to international HRV guidelines. There were no differences in HRV in patients with AD or VAD when compared with controls.



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References

  1. Beere PA, Glagov S, Zarins CK: Retarding effect of lowered heart rate on coronary atherosclerosis. Science 1984;226:180–182.
  2. Beere PA, Glagov S, Zarins CK: Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey: Localization, compensatory enlargement, and the sparing effect of lowered heart rate. Arterioscler Thromb 1992;12:1245–1253.
  3. Rubanyi GM, Romero JC, Vanhoutte PM: Flow-induced release of endothelium-derived relaxing factor. Am J Physiol 1986;250:H1145–1149.
  4. Perry E, Haroutunian V, Davies KL: Neocortical cholinergic activities differentiate Lewy body dementia from Alzheimer’s disease. Neuroreport 1994;5:747–749.
  5. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ: Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control. Science 1981;213:220–222.
  6. Malliani A, Pagani M, Lombardi F, Cerutti S: Cardiovascular neural regulation explored in the frequency domain. Circulation 1991;84:482–492.
  7. Bellavere F, Balzani I, De Masi G, Carraro M, Carenza P, Cobelli C, Thomaseth K: Power spectral analysis of heart-rate variations improves assessment of diabetic cardiac autonomic neuropathy. Diabetes 1992;41:633–640.
  8. Aharon-Peretz J, Harel T, Revach M, Ben-Haim SA: Increased sympathetic and decreased parasympathetic cardiac innervation in patients with Alzheimer’s disease. Arch Neurol 1992;49:919–922.
  9. Giubilei F, Strano S, Imbimbo BP, Tisei P, Calcagnini G, Lino S, Frontoni M, Santini M, Fieschi C: Cardiac autonomic dysfunction in patients with Alzheimer disease: Possible pathogenetic mechanisms. Alzheimer Dis Assoc Disord 1998;12:356–361.
  10. Korpelainen JT, Huikuri HV, Sotaniemi KA, Myllyla VV: Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction. Acta Neurol Scand 1996;94:337–342.
  11. Korpelainen JT, Sotaniemi KA, Huikuri HV, Myllyla VV: Abnormal heart rate variability as a manifestation of autonomic dysfunction in hemispheric brain infarction. Stroke 1996;27:2059–2063.
  12. Korpelainen JT, Sotaniemi KA, Huikuri HV, Myllyla VV: Circadian rhythm of heart rate variability is reversibly abolished in ischemic stroke. Stroke 1997;28:2150–2154.
  13. Tokgozoglu SL, Batur MK, Topuoglu MA, Saribas O, Kes S, Oto A: Effects of stroke localization on cardiac autonomic balance and sudden death. Stroke 1999;30:1307–1311.
  14. McKhann G, Drachman D, Folstein M: Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS ADRDA work group under the auspices of the Department of Health and Human Services Task forces on Alzheimer’s disease. Neurology 1984;34:939–944.
  15. Roman GC, Tatemichi TK, Erkinjutti T: Vascular dementia – Diagnostic criteria for research studies: Report of the NINDS AIREN International Workshop. Neurology 1993;43:250–260.
  16. Folstein MF, Folstein SE, McHugh PR: ‘Mini-mental state’: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98.
  17. Huppert FA, Brayne C, Gill C, Paykel ES, Beardsall L: CAMCOG – A concise neuropsychological test to assist dementia diagnosis: Socio-demographic determinants in an elderly population sample. Br J Clin Psychol 1995;34:529–541.
  18. Lord SW, Senior RR, Das M, Whittam AM, Murray A, McComb JM: Low-frequency heart rate variability: Reproducibility in cardiac transplant recipients and normal subjects. Clin Sci 2001;100:43–46.
  19. Anonymous: Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996;93:1043–1065.
  20. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ: Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256–262.
  21. Ballard C, Shaw F, McKeith I, Kenny R: High prevalence of neurovascular instability in neurodegenerative dementias. Neurology 1998;51:1760–1762.
  22. Ballard C, O’Brien J, Barber B, Scheltens P, Shaw F, McKeith I, Kenny RA: Neurocardiovascular instability, hypotensive episodes, and MRI lesions in neurodegenerative dementia. Ann NY Acad Sci 2000;903:442–445.
  23. Passant U, Warkentin S, Karlson S, Nilsson K, Edvinsson L, Gustafson L: Orthostatic hypotension in organic dementia: Relationship between blood pressure, cortical blood flow and symptoms. Clin Auton Res 1996;6:29–36.
  24. Passant U, Warkentin S, Gustafson L: Orthostatic hypotension and low blood pressure in organic dementia: A study of prevalence and related clinical characteristics. Int J Geriatr Psychiatry 1997;12:395–403.
  25. Parati G, Di Rienzo M, Omboni S, Mancia G: Computer analysis of blood pressure and heart rate variability in subjects with normal and abnormal autonomic cardiovascular control; in Mathias CJ, Bannister R (eds): Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford, Oxford University Press, 1999, pp 211–223.


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