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Table of Contents
Vol. 74, No. 3, 2005
Issue release date: April 2005
Psychother Psychosom 2005;74:173–178
(DOI:10.1159/000084002)

Tridimensional Personality Questionnaire Factors in Major Depressive Disorder: Relationship to Anxiety Disorder Comorbidity and Age of Onset

Öngür D. · Farabaugh A. · Iosifescu D.V. · Perlis R. · Fava M.
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, WACC 812, Boston, Mass., USA

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Abstract

Objective: We used the Tridimensional Personality Questionnaire (TPQ) to study the relationship between temperamental traits and comorbid anxiety disorders as well as age of onset of major depressive disorder (MDD) in 263 patients with MDD. Methods: Patients recruited for a large clinical study on MDD underwent a Structured Clinical Interview for DSM-III-R assessment and were administered the self-rated TPQ [mean age = 39.5 ± 10.5 years, women = 138 (53%), initial 17-item Hamilton Rating Scale for Depression (HAM-D-17) score = 19.6 ± 3.4]. The TPQ was scored for three previously identified factors – harm avoidance (HA), novelty seeking (NS), and reward dependence (RD). Multiple linear regression methods were used to evaluate the relationship between TPQ factors and each comorbid anxiety disorder as well as between early- vs. late-onset MDD, after controlling for age, gender and initial HAM-D-17 score (when these were related to the dependent variable in simple regressions). Results: Social anxiety disorder in MDD was strongly associated with higher scores on HA and lower scores on NS and RD (t = 5.4, p < 0.0001; t = 2.6, p = 0.009; t = 2.2, p = 0.028, respectively). A diagnosis of generalized anxiety disorder in MDD was significantly related to higher HA scores (t = 2.8, p = 0.006). The presence of comorbid obsessive-compulsive disorder was associated with lower NS scores (t = 2.3, p = 0.023) as was that of comorbid panic disorder (t = 2.0, p = 0.051). Finally, the presence of simple phobias was associated with lower scores on RD (t = 2.4, p = 0.016). HA scores were higher in patients with early onset of MDD (adjusted p = 0.05). Early versus late onset of MDD was not significantly related to NS or RD scores. Limitations: Since our sample consisted of moderately depressed outpatients, our ability to generalize our findings to other populations is limited. Conclusions: Features of temperament are related to patterns of anxiety disorder comorbidity and age of onset among patients with MDD. Higher levels of HA and lower levels of RD and NS were associated with an increased risk of anxiety disorder comorbidity in our sample. HA may also be related to early onset of depression.



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References

  1. Fava M, Bouffides E, Pava JA, McCarthy MK, Steingard RJ, Rosenbaum JF: Personality disorder comorbidity with major depression and response to fluoxetine treatment. Psychother Psychosom 1994;62:160–167.
  2. Fava M, Farabaugh AH, Sickinger AH, Wright E, Alpert JE, Sonawalla S, Nierenberg AA, Worthington JJ 3rd: Personality disorders and depression. Psychol Med 2002;32:1049–1057.
  3. Newman JR, Ewing SE, McColl RD, Borus JS, Nierenberg AA, Pava J, Fava M: Tridimensional personality questionnaire and treatment response in major depressive disorder: A negative study. J Affect Disord 2000;57:241–247.
  4. Cloninger CR: A systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 1987;44:573–588.
  5. Brown SL, Svrakic DM, Przybeck TR, Cloninger CR: The relationship of personality to mood and anxiety states: A dimensional approach. J Psychiatr Res 1992;26:197–211.
  6. Svrakic DM, Przybeck TR, Cloninger CR: Mood states and personality traits. J Affect Disord 1992;24:217–226.
  7. Joffe RT, Bagby M, Levitt AJ, Regan JJ, Parker JDA: The tridimensional personality questionnaire in major depression. Am J Psychiatry 1993;150:959–960.
  8. Mulder RT, Joyce PR: Relationships of the tridimensional personality questionnaire to mood and personality measures for depressed patients. Psychol Rep 1994;75:1315–1325.
  9. Strakowski SM, Dunayevich E, Keck PE, McElroy SL: Affective state dependence of the tridimensional personality questionnaire. Psychiatry Res 1995;57:209–214.
  10. Kennedy BL, Schwab JJ, Hyde JA: Defense styles and personality dimensions of research subjects with anxiety and depressive disorders. Psychiatr Q 2001;72:251–262.
  11. Ampollini P, Marchesi C, Signifredi R, Ghinaglia E, Scardovi F, Codeluppi S, Maggini C: Temperament and personality features in patients with major depression, panic disorder and mixed conditions. J Affect Disord 1999;52:203–207.
  12. Van der Does W, Duijsens I, Eurelings-Bontekoe E, Verschur M, Spinhoven P: Anxiety sensitivity profile: Dimensional structure and relationship with temperament and character. Psychother Psychosom 2003;72:217–222.
  13. Grucza RA, Przybeck TR, Spitznagel EL, Cloninger CR: Personality and depressive symptoms: A multi-dimensional analysis. J Affect Disord 2003;74:123–130.
  14. Mulder RT: Personality pathology and treatment outcome in major depression: A review. Am J Psychiatry 2002;159:359–371.
  15. Hellerstein DJ, Kocsis JH, Chapman D, Stewart JW, Harrison W: Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: Effects on personality. Am J Psychiatry 2000;157:1436–1444.
  16. Peselow ED, Sanfilipo MP, Fieve RR, Gulbenkian G: Personality traits during depression and after clinical recovery. Br J Psychiatry 1994;164:349–354.
  17. Petersen T, Hughes M, Papakostas GI, Kant A, Fava M, Rosenbaum JF, Nierenberg AA: Treatment-resistant depression and Axis II comorbidity. Psychother Psychosom 2002;71:269–274.
  18. Ruini C, Ottolini F, Rafanelli C, Tossani E, Ryff CD, Fava GA: The relationship of psychological well-being to distress and personality. Psychother Psychosom 2003;72:268–275.
  19. Fava M, Alpert JE, Borus JS, Nierenberg AA, Pava JA, Rosenbaum JF: Patterns of personality disorder comorbidity in early-onset versus late-onset major depression. Am J Psychiatry 1996;153:1308–1312.
  20. Parker G, Roy K, Hadzi-Pavlovic D, Mitchell P, Wilhelm K: Distinguishing early and late onset non-melancholic unipolar depression. J Affect Disord 2003;74:131–138.
  21. Spitzer RL, Williams JBW, Gibbon M, First MB: Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P). New York, Biometrics Research Department, 1989.
  22. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.
  23. Fava M, Rankin MA, Wright EC, Alpert JE, Nierenberg AA, Pava J, Rosenbaum JF: Anxiety disorders in major depression. Compr Psychiatry 2002;41:97–102.
  24. Alpert JE, Fava M, Uebelacker LA, Nierenberg AA, Pava JA, Worthington JJ 3rd, Rosenbaum JF: Patterns of axis I comorbidity in early-onset versus late-onset major depressive disorder. Biol Psychiatry 1999;46:202–211.
  25. Chien AJ, Dunner DL: The Tridimensional Personality Questionnaire in depression: State versus trait issues. J Psychiatr Res 1996;30:21–27.
  26. Pelissolo A, Corruble E: Personality factors in depressive disorders: Contribution of the psychobiologic model developed by Cloninger. Encephale 2002;28:363–373.


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