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Table of Contents
Vol. 72, No. 3, 2005
Issue release date: April 2005
Section title: Original Paper
Pathobiology 2005;72:133–138
(DOI:10.1159/000084116)

A Single Nucleotide Polymorphism in the 5′ Untranslated Region of the EGF Gene Is Associated with Occurrence and Malignant Progression of Gastric Cancer

Hamai Y. · Matsumura S. · Matsusaki K. · Kitadai Y. · Yoshida K. · Yamaguchi Y. · Imai K. · Nakachi K. · Toge T. · Yasui W.
Departments of aMolecular Pathology and bMedicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, cDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, and dDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima; eDepartment of Surgery, Hofu Institute of Gastroenterology, Yamaguchi, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/22/2004
Accepted: 8/26/2004
Published online: 4/21/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

Objective: Epidermal growth factor (EGF) has many biological functions and plays an important role in the progression of various tumors including gastric cancer. An A-G single nucleotide polymorphism (SNP) at position 61 in the 5′-untranslated region (UTR) of the EGF gene has recently been reported to be associated with different levels of EGF production. We examined whether this polymorphism is correlated with the development and malignant phenotypes of gastric cancer. Methods: The study population included 200 gastric cancer patients and 230 healthy control subjects. The SNP in the 5′-UTR of the EGF gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results: The A allele was significantly less frequent in patients than in controls (p = 0.01). Individuals with the A/A or A/G genotype showed a significantly lower risk of gastric cancer than those with the G/G genotype [adjusted odds ratio (OR) = 0.56], whereas the same genotypes were associated with malignant progression of this cancer, e.g. deeper tumor invasion, increased lymph node metastasis and advanced clinical stage, and histological classification in gastric cancer patients (adjusted OR = 1.80, 1.98, 2.26 and 1.89, respectively). Conclusions: Our findings suggest that the A-G polymorphism of EGF is involved not only in the occurrence but also in the malignant progression of gastric cancer.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/22/2004
Accepted: 8/26/2004
Published online: 4/21/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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