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Vol. 63, No. 2, 2005
Issue release date: April 2005
Section title: Original Paper
Horm Res 2005;63:95–101
(DOI:10.1159/000084156)

Total Pubertal Growth and Markers of Puberty Onset in Adolescents with GHD: Comparison between Mathematical Growth Analysis and Pubertal Staging Methods

Martin D.D. · Hauspie R.C. · Ranke M.B.
aUniversity Children’s Hospital, Tübingen, Germany and bLaboratorium Antropogenetica, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/14/2004
Accepted: 1/13/2005
Published online: 4/6/2005

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Two methods of determining puberty onset (Preece- Baines model 1 (PB1) and Tanner staging) were used to calculate total pubertal growth (TPG) in adolescents with growth hormone deficiency (GHD). Patients and Methods: 34 patients (11 girls) met the following inclusion criteria: isolated GHD, >2 years growth hormone therapy prior to puberty onset, regular weight-adjusted GH dosage, known final height (age >21 years or height velocity <0.5 cm/year), no induction of puberty. PB1 was used to define age and height at onset of the pubertal growth spurt (‘take-off’). Results: The results (mean ± SD) were as follows: in girls, mean age at take-off was 9.8 years; 2.0 ± 1.1 years before breast stage B2. In boys, mean age at take-off was 11.3 years; 1.4 ± 0.8 years before testes volume >3 ml. Height at take-off was lower than at Tanner stage 2 by 12.4 ± 7.6 cm in girls and 7.7 ± 5.3 cm in boys. TPG was thus markedly greater (p < 0.001) using the PB1 method, as compared with Tanner stage2. Peak height velocity was normal. Final height was –0.5 ± 0.7 SDS in females and –0.4 ± 0.9 SDS in males. Conclusions: The method of measuring TPG from take-off is more objective, and has potentially greater implications for GH therapeutics than the Tanner stage method. In our study, 40% of TPG occurred before ‘breast stage B2’ was attained in GHD girls; whereas 23% of TPG occurred before ‘testes >3 ml’ in GHD boys.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/14/2004
Accepted: 1/13/2005
Published online: 4/6/2005

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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