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Vol. 28, No. 2, 2005
Issue release date: 2005
Section title: Original Paper
Kidney Blood Press Res 2005;28:111–116
(DOI:10.1159/000084254)

Comparison of the Effects of Quinapril and Losartan on Carotid Artery Intima-Media Thickness in Patients with Mild-to-Moderate Arterial Hypertension

Uchiyama-Tanaka Y. · Mori Y. · Kishimoto N. · Fukui M. · Nose A. · Kijima Y. · Yamahara H. · Hasegawa T. · Kosaki A. · Matsubara H. · Iwasaka T.
aDepartment of Medicine II, Kansai Medical University, Osaka and bDepartment of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/20/2004
Published online: 4/13/2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Background: Ultrasonographic evidence of increased carotid intima-media thickness (IMT) is known to be associated with generalized atherosclerosis. Therapeutic blockade of the renin-angiotensin system (RAS) with angiotensin-converting enzyme (ACE) inhibitors reportedly reduces carotid IMT in humans. However, there has been no head-to-head comparison of the effects of ACE inhibitor and angiotensin receptor blocker (ARB), a newer type of RAS inhibitor, on carotid IMT. Methods: 57 hypertensive patients were randomly assigned to treatment with one of two antihypertensive drugs: ACE inhibitor (quinapril; n = 25, group Q) or ARB (losartan; n = 18, group L). Results: After 1 year of treatment, a similar decrease in mean blood pressure was observed in all groups. Carotid IMT was decreased significantly in group Q (10% decrease, p < 0.05) but did not change in group L. There were no significant changes in other atherosclerotic factors between these two groups. Conclusion: Our findings suggest that the antiatherosclerotic effect of quinapril is more potent than that of losartan in hypertensive patients. This effect appears unrelated to the drug’s antihypertensive action or to traditional atherosclerotic factors.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/20/2004
Published online: 4/13/2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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