Vol. 48, No. 4, 2005
Issue release date: July–August 2005
Intervirology 2005;48:268–272
Case Report
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Primary Sclerosing Cholangitis and Hepatitis C Virus Infection

Kim S.R.a · Imoto S.a · Taniguchi M.b · Kim K.I.c · Sasase N.c · Matsuoka T.d · Maekawa Y.a · Ninomiya T.a · Ando K.a · Mita K.a · Fuki S.a · Koterazawa T.a · Fukuda K.a · Kudo M.e · Sakamoto H.e · Hayashi Y.f
aDepartment of Gastroenterology, bMedical Information Center, and cDepartment of Pharmacy, Kobe Asahi Hospital, Kobe; dDepartment of Radiology, Osaka City University Medical School, Osaka; eDepartment of Gastroenterology, Kinki University School of Medicine, Osakasayama, and fDivision of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment (ICMRT), Kobe University Graduate School of Medicine, Kobe, Japan
email Corresponding Author

 goto top of outline Key Words

  • Primary sclerosing cholangitis
  • Hepatitis C virus
  • Endoscopic retrograde cholangiopancreatography
  • Human leukocyte antigen
  • Onionskin lesion

 goto top of outline Abstract

Two cases of primary sclerosing cholangitis with hepatic C virus infection in a 62-year-old man and a 60-year-old woman are presented. The infection in the man was eradicated with interferon therapy in 1992. Seven years thereafter, endoscopic retrograde cholangiography revealed a diffuse 2.5-cm-long stenotic lesion in the common bile duct which was consequently resected. Histological examination of the resected specimen revealed proliferation of epithelial cells, plasma cell infiltration, and fibrosis in the submucosal layer of the common bile duct. The human leukocyte antigen DR loci were 2 and 9. In the woman, a 6-month course of interferon therapy in 1992 failed to eradicate the infection. Cholangiography in 1999 revealed multiple narrowings and dilatations of intra- and extrahepatic bile ducts. Ultrasound guided biopsy of the liver in 1992 had revealed onionskin lesions around the bile duct epithelium in the portal tract. The human leukocyte antigen DR locus was 2. From these findings, the 2 cases were diagnosed as primary sclerosing cholangitis. Further studies may provide insights into the relation between the pathogenesis of the disease and the infection.

Copyright © 2005 S. Karger AG, Basel

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 goto top of outline Author Contacts

Soo Ryang Kim, MD
Department of Gastroenterology, Kobe Asahi Hospital
3-5-25 Bouoji-cho
Nagata-ku, Kobe 653-0801 (Japan)
Tel. +81 78 612 5151, Fax +81 78 612 5152, E-Mail asahi-hp@arion.ocn.ne.jp

 goto top of outline Article Information

Received: April 23, 2004
Accepted after revision: August 12, 2004
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 0, Number of References : 45

 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 48, No. 4, Year 2005 (Cover Date: July-August 2005)

Journal Editor: Liebert, U.G. (Leipzig)
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/int

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