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Vol. 67, No. 2, 2005
Issue release date: 2005

Inflammatory Myofibroblastic Tumor of the Larynx in a 2-Year-Old Male

Rodrigues M. · Taylor R.J. · Sun C.-C. · Wolf J.S.
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Abstract

Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm that is usually located in the lung in the pediatric population. These tumors contain a variety of cell types with the myofibroblast being dominant. When located in the upper airway, IMTs tend to be less aggressive, but have the potential for local invasion and recurrence. We present an unusual case of IMT in the pediatric larynx and review the medical literature describing the common locations, diagnosis, etiology, histology, and treatment of this tumor. The mainstay of treatment is complete surgical excision. Careful and frequent follow-up including frequent fiberoptic laryngoscopy and CT scans are recommended to evaluate for recurrence. More aggressive resection may be necessary if multiple recurrences occur.



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References

  1. Coffin CM, Dehner LP, Meis-Kindblom JM: Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: An historical review with differential diagnostic considerations. Semin Diagn Pathol 1998;15:102–110.
  2. Wenig BM, Devaney K, Bisceglia M: Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer 1995;76:2217–2229.
  3. Meis-Kindblom JM, Kjellstrom C, Kindblom LG: Inflammatory fibrosarcoma: Update, reappraisal, and perspective on its place in the spectrum of inflammatory myofibroblastic tumors. Semin Diagn Pathol 1998;15:133–143.
  4. Wang QP, Escudier E, Roudot-Thoraval F, Abd-Al Samad I, Peynegre R, Coste: Myofibroblast accumulation induced by transforming growth factor-beta is involved in the pathogenesis of nasal polyps. Laryngoscope 1997:107:926–931.
  5. Doucet C, Brouty-Boye D, Pottin-Clemenceau C, Canonica GW, Jasmin C, Azzarone B: Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Invest 1998;101:2129–2139.
  6. Brenner DA, Waterboer T, Choi SK, Lindquist JN, Stefanovic B, Burchardt E, Yamauchi M, Gillan A, Rippe RA: New aspects of hepatic fibrosis. J Hepatol 2000;32(1 suppl):32–38.
  7. Gabbiani G, Ryan GB, Majne G: Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971;27:549–550.
  8. Desmouliere A: Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 1995;19:471–476.
  9. Albores-Saavedra J, Manivel JC, Essenfeld H, Dehner LP, Drut R, Gould E, Rosai J: Pseudosarcomatous myofibroblastic proliferations in the urinary bladder of children. Cancer 1990;66:1234–1241.
  10. Lacson A, Washington K, Tuite G, Nuttall R: Pathological case of the month. Intracranial plasma cell granuloma. Arch Pediatr Adolesc Med 2001;155:851–852.
  11. Donner LR, Trompler RA, White RRT: Progression of inflammatory myofibroblastic tumor (inflammatory pseudotumor) of soft tissue into sarcoma after several recurrences. Hum Pathol 1996;27:1095–1098.
  12. Coffin CM, Watterson J, Priest JR, Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995,19:859–872.
  13. Meis JM, Enzinger FM: Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol 1991;15:1146–1156.
  14. Arber DA, Kamel OW, van de Rijn M, Davis RE, Medeiros LJ, Jaffe ES, Weiss LM: Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol 1995;26:1093–1098.
  15. Treissman SP, Gillis DA, Lee CL, Giacomantonio M, Resch L: Omental-mesenteric inflammatory pseudotumor. Cytogenetic demonstration of genetic changes and monoclonality in one tumor. Cancer 1994;73:1433–1437.
  16. Corsi A, Ciofalo A, Leonardi M, Zambetti G, Bosman C: Recurrent inflammatory myofibroblastic tumor of the glottis mimicking malignancy. Am J Otolaryngol 1997;18:121–126.
  17. Amir R, Danahey D, Ferrer K, Maffee M: Inflammatory myofibroblastic tumor presenting with tracheal obstruction in a pregnant woman. Am J Otolaryngol 2002;23:362–367.
  18. Ereno C, Lopez JI, Grande J, Santaolalla F, Bilbao FJ: Inflammatory myofibroblastic tumour of the larynx. J Laryngol Otol 2001;115:856–858.


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