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Vol. 18, No. 4, 2005
Issue release date: July–August 2005
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2005;18:195–200
(DOI:10.1159/000085865)

Protective Effects of Different Marigold (Calendula officinalis L.) and Rosemary Cream Preparations against Sodium-Lauryl-Sulfate-Induced Irritant Contact Dermatitis

Fuchs S.M. · Schliemann-Willers S. · Fischer T.W. · Elsner P.
Department of Dermatology and Allergology, Friedrich-Schiller University Jena, Jena, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/19/2004
Accepted: 1/18/2005
Published online: 6/21/2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex = German Pharmaceutical Codex) were tested in a 4-day repetitive irritation test using sodium lauryl sulfate. The effect was evaluated visually and quantified by noninvasive bioengineering methods, namely chromametry and tewametry. When the test products were applied parallel to the induction period of ICD, a statistically significant protective effect of all cream preparations was observed by all methods. This effect, although not statistically significant, was superior to control by undyed marigold und faradiol ester-enriched extracts in chromametry and by dyed and undyed rosemary extracts in tewametry. The sequential treatment (postirritation) once a day for 5 days was without any effect. Thus, a protective effect of some marigold and rosemary extracts against ICD could be shown in the elicitation phase.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/19/2004
Accepted: 1/18/2005
Published online: 6/21/2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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