Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Protective Effects of Different Marigold (Calendula officinalis L.) and Rosemary Cream Preparations against Sodium-Lauryl-Sulfate-Induced Irritant Contact Dermatitis

Fuchs S.M. · Schliemann-Willers S. · Fischer T.W. · Elsner P.
Department of Dermatology and Allergology, Friedrich-Schiller University Jena, Jena, Germany Skin Pharmacol Appl Skin Physiol 2005;18:195–200 (DOI:10.1159/000085865)

Abstract

In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex = German Pharmaceutical Codex) were tested in a 4-day repetitive irritation test using sodium lauryl sulfate. The effect was evaluated visually and quantified by noninvasive bioengineering methods, namely chromametry and tewametry. When the test products were applied parallel to the induction period of ICD, a statistically significant protective effect of all cream preparations was observed by all methods. This effect, although not statistically significant, was superior to control by undyed marigold und faradiol ester-enriched extracts in chromametry and by dyed and undyed rosemary extracts in tewametry. The sequential treatment (postirritation) once a day for 5 days was without any effect. Thus, a protective effect of some marigold and rosemary extracts against ICD could be shown in the elicitation phase.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50