- Chronic hepatitis B
- Antiviral response
- HBeAg seroconversion
Objective: The aim of this study was to evaluate retrospectively the long-term effects of lamivudine in 461 Korean patients with chronic hepatitis B who were treated for more than 12 months. Methods: The annual rates of virological response and breakthrough were examined and the predictive factors for post-treatment relapse in 114 patients who achieved hepatitis B e antigen (HBeAg) loss or seroconversion after lamivudine therapy were also analyzed. Results: During follow-up, the rates of HBeAg seroconversion after 1, 2, 3, 4 and 5 years of treatment were 22.9, 33.2, 47.6, 54.2 and 58.8%, respectively, while those for virological breakthrough at 1, 2, 3 and 4 years were 8.2, 41.7, 55.7 and 64.8%, respectively. Ninety-five patients (20.6%) had HBeAg seroconversion and 19 (4.1%) showed HBeAg loss alone with disappearance of hepatitis B virus DNA in serum. Seroconversion was higher with prolonged treatment in patients who had elevated serum alanine aminotransferase. The cumulative relapse rates in the seroconversion group were 52.0 and 55.7% 1 and 2 years after treatment, respectively. Age and the duration of additional treatment were significant predictive factors for post-treatment relapse. Patients aged ≤40 who had additional treatment for >12 months after seroconversion had the lowest relapse rate (p < 0.001). Conclusions: These results suggest that additional treatment for over 12 months after HBeAg seroconversion in younger patients may produce a better long-term outcome.
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Seung Kew Yoon, MD
Department of Internal Medicine, Kangnam St. Mary’s Hospital
Catholic University of Korea, No. 505 Banpo-dong, Seocho-ku
Seoul 137-040 (South Korea)
Tel. +82 2 590 2622, Fax +82 2 3481 4025, E-Mail email@example.com
Received: August 27, 2004
Accepted after revision: November 22, 2004
Number of Print Pages : 9
Number of Figures : 7, Number of Tables : 5, Number of References : 35
Intervirology (International Journal of Basic and Medical Virology)
Vol. 48, No. 6, Year 2005 (Cover Date: November-December 2005)
Journal Editor: Liebert, U.G. (Leipzig)
ISSN: 0300–5526 (print), 1423–0100 (Online)
For additional information: http://www.karger.com/int
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