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Vol. 211, No. 2, 2005
Issue release date: 2005

Drug-Induced Hypersensitivity Syndrome due to Carbamazepine Associated with Reactivation of Human Herpesvirus 7

Hara H. · Kobayashi M. · Yokoyama A. · Tochigi M. · Matsunaga A. · Shimizu H. · Goshima J. · Suzuki H.
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We report a 63-year-old Japanese man with epilepsy who developed skin eruptions, liver dysfunction, high fever, leukocytosis and atypical lymphocytosis 4 weeks after he had started taking carbamazepine. Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by polymerase chain reaction. These findings suggested that reactivation of HHV-7 could contribute to the development of drug-induced hypersensitivity syndrome.

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