Mechanisms of Epithelial Defense

Editor(s): Kabelitz D. (Kiel) 
Schröder J.-M. (Kiel) 
Table of Contents
Vol. 86, No. , 2005
Section title: Paper
Kabelitz D, Schröder J-M (eds): Mechanisms of Epithelial Defense. Chem Immunol Allergy. Basel, Karger, 2005, vol 86, pp 151-183

γδ T Cells Link Innate and Adaptive Immune Responses

Focus on Human Vγ9/Vδ2 and Vδ1 T Cells

Holtmeier W. · Kabelitz D.
aMedizinische Klinik I., Johann Wolfgang Goethe-Universität, Frankfurt am Main, and bInstitute of Immunology, UK S-H Campus Kiel, Kiel, Germany

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While most T cells use a CD3-associated α/β T cell receptor as antigen recognition structure, a second population of T cells expresses the alternative γ/δ T cell receptor. γ/δ T cells are a minor population in the peripheral blood but constitute a major population among intestinal intraepithelial lymphocytes. Most γ/δ T cells recognize ligands which are fundamentally different from the short peptides that are seen by α/β T cells in the context of MHC class I or class II molecules. Thus, human Vδ2 T cells recognize small bacterial phosphoantigens, alkylamines and synthetic aminobisphosphonates, whereas Vδ1 T cells recognize stress-inducible MHC-related molecules MICA/B as well as several other ligands. At the functional level, γ/δ T cells rapidly produce a variety of cytokines and usually exert potent cytotoxic activity, also towards many tumor cells. In this article, we discuss the role of γ/δ T cells as a bridge between the innate and the adaptive immune system, based on the interpretation that γ/δ T cells use their T cell receptor as a pattern recognition receptor. Our increasing understanding of the ligand recognition and activation mechanisms of γ/δ T cells also opens new perspectives for the development of γ/δ T cell-based immunotherapies.

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