Vol. 60, No. 1, 2005
Issue release date: 2005
Hum Hered 2005;60:1–9
Original Paper
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Complex Segregation Analysis of Obsessive-Compulsive Disorder in Families with Pediatric Probands

Hanna G.L.a · Fingerlin T.E.b · Himle J.A.a · Boehnke M.c
aDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Mich., bDepartment of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colo. and cDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Mich., USA
email Corresponding Author

 goto top of outline Key Words

  • Obsessive-compulsive disorder
  • Complex segregation analysis
  • Regressive logistic models
  • Age at onset
  • Single major locus transmission

 goto top of outline Abstract

Objective: The purpose of this study was to assess the mode of inheritance for obsessive-compulsive disorder (OCD) in families ascertained through pediatric probands. Methods: We ascertained 52 families (35 case and 17 control families) through probands between the ages of 10 and 17 years. Direct interviews were completed with 215 individuals. Family informant data were collected on another 450 individuals without direct interviews, forming two data sets with one contained within the other. Complex segregation analyses were performed using regressive models as programmed in REGTL in the S.A.G.E. package.All models used in the analyses included sex-specific age and type parameters. Results: All models that excluded a residual effect of an affected parent were rejected. With that parameter included, the environmental and sporadic models were rejected in comparisons with the most general model in both data sets (all p < 0.005). With the direct interview data, the general codominant Mendelian model was not rejected when compared with the most general model (p = 0.140). We could not distinguish between any of the simple Mendelian models using either data set. However, the dominant Mendelian model provided a somewhat better fit than the other Mendelian models to the direct interview data. Conclusions: The results provide evidence for a major susceptibility locus in families with OCD when age at onset is incorporated into the model. Mendelian factors at most partially explained the familial aggregation of the phenotype, and residual familial effects were necessary to fit the data adequately. The results support the importance of linkage efforts by suggesting that a major locus is segregating within a proportion of families with OCD ascertained through pediatric probands.

Copyright © 2005 S. Karger AG, Basel

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 goto top of outline Author Contacts

Gregory L. Hanna, MD
Department of Psychiatry, University of Michigan Health System
2101 Commonwealth Boulevard, Suite C
Ann Arbor, MI 48109-0390 (USA)
Tel. +1 734 764 0234, Fax +1 734 936 8907, E-Mail ghanna@umich.edu

 goto top of outline Article Information

Received: December 23, 2004
Accepted after revision: May 12, 2005
Published online: July 27, 2005
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 1, Number of References : 50

 goto top of outline Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 60, No. 1, Year 2005 (Cover Date: 2005)

Journal Editor: Devoto, M. (Wilmington, Del.)
ISSN: 0001–5652 (print), 1423–0062 (Online)

For additional information: http://www.karger.com/hhe

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