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Vol. 25, No. 4, 2005
Issue release date: October 2005
Section title: Original Paper
Neuroepidemiology 2005;25:163–175
(DOI:10.1159/000087446)

The Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort

Bennett D.A. · Schneider J.A. · Buchman A.S. · Mendes de Leon C. · Bienias J.L. · Wilson R.S.
aRush Alzheimer’s Disease Center, Departments of bNeurological Sciences, cPathology, dPreventive Medicine, eInternal Medicine, and fRush Institute for Healthy Aging, and gPsychology, Rush University Medical Center, Chicago, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/20/2005
Published online: 10/28/2005

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 6

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

The long-term objective of the Rush Memory and Aging Project is to identify the postmortem indices linking genetic and environmental risk factors to the development of Alzheimer’s disease (AD). The overall study design involves a detailed assessment of risk factors for AD in older persons without known dementia who agree to annual clinical evaluation and organ donation at the time of death. In contrast to other clinical-pathologic studies which are conducted on special populations, the Rush Memory and Aging Project enrolled a cohort with much greater diversity in terms of educational attainment, in addition to gender, race, and ethnicity. From September of 1997 through April of 2005, more than 1,000 older persons without known dementia from more than 30 residential facilities across the Chicago metropolitan area agreed to participate. Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/20/2005
Published online: 10/28/2005

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 6

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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