Cognitive Correlates of Cerebral White Matter Lesions and Water Diffusion Tensor Parameters in Community-Dwelling Older PeopleShenkin S.D.a, b · Bastin M.E.c · MacGillivray T.J.e · Deary I.J.b · Starr J.M.a · Rivers C.S.d · Wardlaw J.M.d
Departments of aGeriatric Medicine, bPsychology, cMedical and Radiological Sciences (Medical Physics), dClinical Neurosciences, and eWellcome Trust Clinical Research Facility, University of Edinburgh, Edinburgh, UK Cerebrovasc Dis 2005;20:310–318 (DOI:10.1159/000087930)
Background: The biological basis of cognitive ageing is unknown. One underlying process might be disruption of white matter tracts connecting cortical regions. White matter lesions (WML) seen on structural MRI may disrupt cortical connections, but diffusion tensor MRI (DT-MRI) parameters – mean diffusivity (
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