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Vol. 21, No. 1, 2006
Issue release date: December 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2006;21:16–21
(DOI:10.1159/000089215)

Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease

Nakano S. · Yamashita F. · Matsuda H. · Kodama C. · Yamada T.
aDepartment of Internal Medicine, Fukuoka University, Fukuoka, bNational Center of Neurology and Psychiatry (NCNP), Musashi Hospital,Tokyo, and cDepartment of Nuclear Medicine, Saitama Medical School Hospital, Saitama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 12/15/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

To investigate the association between delusions and cerebral functional deficits in Alzheimer’s disease (AD), we evaluated probable AD patients with and without delusions. Methods: Functional brain imaging was performed by single photon emission computed tomography with technetium-99m-labeled ethyl cysteinate dimer (99mTc-ECD) in 64 AD patients and 76 age-matched normal healthy volunteers. SPECT data were analyzed by statistical parametric mapping. Results: In AD patients, no differences were found in age and cognitive activities between those with (n = 25) and without (n = 39) delusions. Compared with normal healthy volunteers, AD patients had significantly decreased perfusion in the posterior cingulate gyri, precunei, and parietal association cortex. Moreover, in the patients with delusions, perfusion was significantly decreased in the frontal lobe with right side dominance. In the comparison between the patients with and without delusions, the patients with delusions had significantly decreased perfusion in the prefrontal cortex, anterior cingulate gyri, inferior to middle temporal cortices, and parietal cortex of the right hemisphere (p < 0.01). Conclusion: The functional deficits in the right hemisphere may be the cause of delusions in AD.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 12/15/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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