Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Side Effects of Oral Iron Prophylaxis in Pregnancy – Myth or Reality?

Milman N.a, b · Byg K.-E.b · Bergholt T.a · Eriksen L.a
aDepartment of Obstetrics, Gentofte Hospital, and bDepartment of Medicine B, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Acta Haematol 2006;115:53–57 (DOI:10.1159/000089466)

Abstract

Background: It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects. Objective: To assess the gastrointestinal side effects of iron prophylaxis in pregnancy. Methods: A randomized, double-blind study comprising 404 healthy pregnant women allocated to four groups taking ferrous iron supplement (as fumarate) in doses of 20 (n = 99), 40 (n = 100), 60 (n = 102) and 80 mg (n = 103) daily from 18 weeks of gestation to delivery. Iron supplement was predominantly taken at bedtime. Gastrointestinal symptoms (nausea, vomiting, epigastric pain, eructation, pyrosis, meteorism, borborygmi, colic pain, flatulence, constipation, thin feces, diarrhea), black feces, and use of laxatives were recorded by interview at 18, 32 and 39 weeks of gestation. Results: The frequencies of gastrointestinal symptoms were not significantly different in the four iron supplement groups either at inclusion or at 32 and 39 weeks of gestation and thus not related to the iron dose. Conclusion: This study shows that a supplement of 20–80 mg ferrous iron (as fumarate), taken between meals, has no clinically significant gastrointestinal side effects. The implementation of iron prophylaxis to pregnant women should not be compromised by undue concern of non-existing side effects.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50