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Vol. 28, No. 5-6, 2005
Issue release date: March 2006
Section title: Current Issues in Chronic Renal Failure
Kidney Blood Press Res 2005;28:307–310
(DOI:10.1159/000090185)

Hypoalbuminemia in Renal Failure: Pathogenesis and Therapeutic Considerations

Haller C.
Medizinische Klinik I, Hegau-Bodensee-Klinikum, Singen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Current Issues in Chronic Renal Failure

Published online: 3/20/2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Hypoalbuminemia is common in patients with end-stage renal disease (ESRD). It is caused by a combination of a reduced synthesis and an increased degradation of albumin. The altered albumin homeostasis in ESRD patients is caused by a systemic inflammatory state which correlates closely with mortality. Hypoalbuminemia is a strong predictor of an adverse prognosis, but it is not a pathogenic factor in itself. In critically ill patients in intensive care units, the intravenous administration of human serum albumin generally does not improve prognosis. In contrast, in hypoalbuminemic dialysis patients with volume overload and a reduced effective arterial volume the administration of albumin is based on the pathophysiological concept of increasing intravascular oncotic pressure to transfer extravascular fluid into the intravascular compartment for ultrafiltration in order to mobilize edema fluid.


Article / Publication Details

First-Page Preview
Abstract of Current Issues in Chronic Renal Failure

Published online: 3/20/2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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