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Table of Contents
Vol. 105, No. 2, 2006
Issue release date: February 2006
Section title: Original Research
Cardiology 2006;105:113–118
(DOI:10.1159/000090212)

Association of the Phe206Leu Allele of the L-Selectin Gene with Coronary Artery Disease

Hajilooi M. · Tajik N. · Sanati A. · Eftekhari H. · Massoud A.
Departments of Immunology,aMolecular Medicine Research Center, Hamedan University of Medical Sciences, Hamedan, bIran University of Medical Sciences and cTehran University of Medical Sciences, Tehran, and dDepartment of Cardiology, Tehran University of Medical Sciences, Tehran, Iran; eDepartment of Internal Medicine, University of Texas-Houston, Houston, Tex., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/9/2005
Accepted: 8/20/2005
Published online: 2/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Background and Aims: The aim of this study was to assess the association between the L-selectin Phe206Leu polymorphism and coronary artery disease. Methods: A total of 322 patients (221 men and 101 women) with coronary artery disease in one or more vessels documented by angiography were studied; 157 subjects (85 men and 72 women) without atherosclerosis were included as controls. All subjects were genotyped for the L-selectin Phe206Leu gene polymorphism using polymerase chain reaction with sequence-specific primer (PCR-SSP). To assess disease severity, all patients were classified by numbers of coronary arteries with 50% stenosis. Results: A significantly increased frequency of the 206Leu mutant allele was observed in patients with coronary artery disease compared to the controls. The 206Leu allele frequency occurred in 42% of the patients with coronary artery disease compared to 30% of the controls (p < 0.009). No association was found between the severity of coronary artery disease and the L-selectin Phe206Leu polymorphism. Conclusion: Our findings suggest that carriage of L-selectin 206Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease.


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/9/2005
Accepted: 8/20/2005
Published online: 2/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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