Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 21, No. 2, 2006
Issue release date: January 2006
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2006;21:88–96

The Efficacy of Omega–3 Fatty Acids on Cognitive Function in Aging and Dementia: A Systematic Review

Issa A.M.a, b · Mojica W.A.a · Morton S.C.a · Traina S.a, b, c · Newberry S.J.a · Hilton L.G.a · Garland R.H.a · MacLean C.H.a, c, d
The Southern California Evidence-Based Practice Center –aRAND Health, Santa Monica, Calif., Schools of bPublic Health and cMedicine, University of California, dThe Greater Los Angeles VA Medical Center, Los Angeles, Calif., USA
email Corresponding Author

Amalia M. Issa, MPH, PhD

RAND Corporation Division of Health

1776 Main Street

Santa Monica, CA 90401 (USA)

E-Mail aissa1@ucla.edu


  1. U.S. General Accounting Office: Alzheimer’s Disease: Estimates of Prevalence in the United States (GAO/HEHS-98-16, 1–45). Washington, U.S. General Accounting Office, 1998.
  2. Hebert LE, Beckett LA, Scherr PA, Evans DA: Annual incidence of Alzheimer disease in the United States projected to the years 2000 to 2050. Alz Dis Assoc Disord 2001;4:169–173.
  3. Haan MN, Wallace R: Can dementia be prevented? Brain aging in a population-based context. Annu Rev Pub Health 2004;25:1–24.
  4. Hashimoto M, Hossain S, Shimada T, Sugioka K, Yamasaki H, Fujii Y, Ishibashi Y, Oka J, Shido O: Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer’s disease model rats. J Neurochem 2002;81:1084–1091.
  5. Favrelere S, Stadelmann-Ingrand S, Huguet F, De Javel D, Piriou A, Tallineau C, Durand G: Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. Neurobiol Aging 2000;21:653–660.
  6. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM: Docosahexaenoic acid protects from dendritic pathology in an Alzheimer’s disease mouse model. Neuron 2004;43:633–664.
  7. Cooper JL: Dietary lipids in the aetiology of Alzheimer’s disease: implications for therapy. Drugs Aging 2003;20:399–418.
  8. Friedland R: Fish consumption and the risk of Alzheimer disease: is it time to make dietary recommendations? Arch Neurol 2003;60:923–924.
  9. http://qualitycounts.com/fpfattyacids.html. Accessed February 10, 2005.
  10. http://www.discount-vitamins-herbs.net/health-news27.htm. Accessed February 10, 2005.
  11. Weil M, Bressler J, Parsons P, Bolla K, Glass T, Schwartz B: Blood mercury levels and neurobehavioral function. JAMA 2005;293:1875–1882.
  12. MacLean CH, Issa AM, Newberry SJ, Mojica WA, Morton SC, Garland RH, Hilton LG, Traina SB, Shekelle PG: Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia, and Neurological Diseases. Evidence Report/Technology Assessment No. 114 (Prepared by the Southern California Evidence-Based Practice Center, under contract No. 290-02-0003). Publication No. 05-E011-2. Rockville, Agency for Healthcare Research and Quality, February 2005.
  13. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1–12.
  14. Downs S, Black N: The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998;52:377–384.
  15. Saunders L, Soomro G, Buckingham J, Jamtvedt G, Raina P: Assessing the methodological quality of nonrandomized intervention studies. West J Nurs Res 2003;25:223–237.
  16. Kalmijn S, Feskens EJ, Launer LJ, Kromhout D: Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 1997;145:33–41.
  17. Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S: Fish, meat, and risk of dementia: cohort study. BMJ 2002;325:932–933.
  18. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J: Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940–946.
  19. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM: Dietary fat intake and the risk of incident dementia in the Rotterdam study. Ann Neurol 1997;42:776–782.
  20. Terano T, Fujishiro S, Ban T, Yamamoto K, Tanaka T, Noguchi Y, Tamura Y, Yazawa K, Hirayama T: Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids 1999;34(suppl):S345–S346.
    External Resources
  21. Willet W: Overview of nutritional epidemiology; in Willet W (ed): Nutritional Epidemiology, ed 2. New York, Oxford University Press, 1998, pp 3–17.
  22. Grimes DA, Schulz KF: Cohort studies: marching towards outcomes. Lancet 2002;359:341–345.
  23. Grimes DA, Schulz KF: Bias and causal associations in observational research. Lancet 2002;359:248–252.