Cover

Allergy and Asthma in Modern Society: A Scientific Approach

Editor(s): Crameri R. (Davos) 
Table of Contents
Vol. 91, No. , 2006
Section title: Paper
Crameri R (ed): Allergy and Asthma in Modern Society: A Scientific Approach. Chem Immunol Allergy. Basel, Karger, 2006, vol 91, pp 59-75
(DOI:10.1159/000090230)

The Role of T Lymphocytes in Asthma

Kay A.
National Heart & Lung Institute, and Leukocyte Biology Section, Imperial College, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/8/2005
Cover Date: 2006

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8000-7 (Print)
eISBN: 978-3-318-01266-8 (Online)

Abstract

There is now overwhelming evidence to support a major role for T cells in asthma, in particular the involvement of T helper type 2 (Th2) cells in atopic allergic asthma as well as nonatopic and occupational asthma. There may also be a minor contribution from T cytotoxic type 2 CD8+T cells. Several Th2 cytokines have potential to modulate airway inflammation, in particular interleukin-13 which induces airway hyperresponsiveness independently of IgE and eosinophilia in animal models. The identification of transcription factors controlling Th1, Th2 and T-regulatory cell (TReg) development further support the Th2 hypothesis since GATA3 is overexpressed and T-bet underexpressed in the asthmatic airway and Foxp3 is induced in asthma by corticosteroid treatment. Specific T-cell-directed immunotherapy may allow induction/modulation of T-cell responses, and elucidation of the mechanisms of TRegs may allow further optimization of immunotherapy. Recent advances in the understanding of dendritic cell function in directing T-cell responses may uncover further therapeutic targets. Efficacy of cyclosporin and anti-CD4 treatment in chronic severe asthma argues for continued T-cell involvement, but whether remodeling contributes to pathology inaccessible to antiinflammatory treatment or T-cell immunotherapy remains an important question.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/8/2005
Cover Date: 2006

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8000-7 (Print)
eISBN: 978-3-318-01266-8 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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