Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Relationship between Lifetime Smoking, Smoking Status at Older Age and Human Cognitive Function

Stewart M.C.W.a · Deary I.J.b · Fowkes F.G.R.a · Price J.F.a
aWolfson Unit for the Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, and bDepartment of Psychology, University of Edinburgh, Edinburgh, UK Neuroepidemiology 2006;26:83–92 (DOI:10.1159/000090253)


Cigarette smoking is a major risk factor for clinical cardiovascular disease and may also be associated with poorer cognitive functioning in older age. We measured lifetime cigarette smoking, smoking status and cognitive function in over 2,000 men and women from the general population aged over 50 years with subclinical atherosclerosis (ankle brachial pressure index ≤0.95 but no history of clinical cardiovascular disease). In this population, an association was found between greater lifetime smoking and poorer cognitive function in men and between smoking cessation and better cognitive function in women. The former relationship appeared to reflect an association between smoking habit and prior cognitive function (in early life), whereas the latter remained significant after adjustment for tests of crystallised cognitive function, suggesting a relationship between continuing to smoke (as opposed to quitting) and age-related cognitive decline. Both relationships were inde pendent of the degree of atherosclerosis (as measured using the ankle brachial pressure index), suggesting alternative underlying mechanisms for the association between smoking and human adult cognitive function.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50