Journal Mobile Options
Table of Contents
Vol. 6, No. 1-2, 2006
Issue release date: April 2006
Section title: Case Report
Pancreatology 2006;6:155–159
(DOI:10.1159/000090257)

Radiofrequency Ablation Has a Valuable Therapeutic Role in Metastatic VIPoma

Moug S.J. · Leen E. · Horgan P.G. · Imrie C.W.
Departments of Surgery and Radiology, Glasgow Royal Infirmary, Glasgow, UK

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 3/3/2005
Accepted: 6/15/2005
Published online: 4/20/2006

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Background: Vasoactive intestinal peptide-secreting tumours (VIPomas) are rare islet cell tumours of the pancreas that can result in life-threatening biochemical abnormalities. The optimal intervention for metastatic VIPoma remains undecided. This case history documents the clinical role of radiofrequency (RF) ablation in the treatment of metastatic VIPoma. Case History: A primary pancreatic VIPoma was diagnosed in a 61-year-old female in 1998 and a distal pancreatectomy and splenectomy were performed. She remained disease-free for 44 months when she presented as an emergency with watery diarrhoea, hypokalaemia, renal failure and an elevated serum VIP level. CT scanning showed a liver metastasis and open RF ablation was performed with complete resolution of symptoms and biochemistry within 48 h. Post-ablation imaging confirmed complete ablation of the metastasis. She remained disease-free until 22 months later when watery diarrhoea resumed and a new hepatic metastasis was seen on CT. Percutaneous RF ablation was performed and follow-up CT scan showed complete ablation of the metastasis. The patient remains disease- and symptom-free 10 months after the second RF ablation. Conclusion: This case illustrates that the pronounced clinical and biochemical upset caused by metastatic VIPoma can be resolved safely, quickly and repeatedly by RF ablation.


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 3/3/2005
Accepted: 6/15/2005
Published online: 4/20/2006

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Delcore R, Friesen SR: Gastrointestinal neuroendocrine tumors. J Am Coll Surg 1994;178:187.
  2. Verner JV, Morrison AB: Islet tumour and a syndrome or refractory watery diarrhoea and hypokalaemia. Am J Med 1958;25:374–380.
  3. Bloom SR, Polak JM, Pearse AGE: Vasoactive intestinal peptide and watery-diarrhea syndrome. Lancet 1973;ii:14–16.
  4. Brentjens R, Saltz L: Islet cell tumors of the pancreas: The medical oncologist’s perspective. Surg Clin North Am 2001;81:527–542.
  5. Capella C, Polak JM, Buffa R, et al: Morphological patterns and diagnostic criteria of VIP-producing endocrine tumors. A histologic, histochemical, ultrastructural and biochemical study of 32 cases. Cancer 1983;52:1860–1874.
  6. Mekhjian HS, O’Dorisio TM: VIPoma syndrome. Semin Oncol 1987;14:282–291.
  7. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodes J: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL conference. J Hepatol 2001;35:421–430.
  8. Solbiati L, Livraghi T, Goldberg SN, Ierace T, Meloni F, Dellanoce M, et al: Percutaneous radiofrequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 2001;221:159–166.
  9. De Baere T, Risse O, Kuoch V, Dromaun C, Sengel C, Smayra T, et al: Adverse events during radiofrequency treatment of 582 hepatic tumors. AJR Am J Roentgenol 2003;181:695–700.
  10. Giorgio A, Tarantino L, de Stefano G, Scala V, Liorre G, Scarano F, et al: Percutaneous sonographically guided saline-enhanced radiofrequency ablation of hepatocellular carcinoma. AJR Am J Roentgenol 2003;181:479–484.
  11. Vilana R, Llovet JM, Bianchi L, Sanchez M, Pages M, Sala M, et al: Contrast-enhanced power Doppler sonography and helical compued tomography for assessment of vascularity of small hepatocellular carcinomas before and after percutaneous ablation. J Clin Utrasound 2003;31:119–128.
  12. Hellman P, Ladjevardi S, Skigseid B, Akerstrom G, Elvin A: Radiofrequency tissue ablation using cooled tip for liver metastases of endocrine tumors. World J Surg 2002;26:1052–1056.
  13. Scott A, Hinwood D, Donnelly R: Radiofrequency ablation for symptom control in a patient with metastatic pancreatic insulinoma. Clin Endocrinol 2002;56:557–559.
  14. Rossi S, Fornari F, Buscarini L: Percutaneous ultrasound-guided radiofrequency electrocautery for the treatment of small hepatocelullar carcinoma. J Interv Radiol 1993;8:97–103.
  15. Soga J, Yakuwa Y: Vipoma/diarrheogenic syndrome: a statistical evaluation of 241 reported cases. J Exp Clin Cancer Res 1998;17:389–400.