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Vol. 2, No. 5, 2005
Issue release date: February 2006
Section title: Special Topic Section: Immunotherapies and Related Strategies in Alzheimer’s ...
Neurodegenerative Dis 2005;2:267–272
(DOI:10.1159/000090367)

Developing Novel Immunogens for an Effective, Safe Alzheimer’s Disease Vaccine

Maier M. · Seabrook T.J. · Lemere C.A.
Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: Immunotherapies and Related Strategies in Alzheimer’s ...

Published online: 2/22/2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Active amyloid β (Aβ) vaccination has been shown to be effective in clearing cerebral Aβ and improving cognitive function in mouse models of Alzheimer’s disease. However, an Aβ vaccine clinical trial was suspended after meningoencephalitis was detected in a subset of subjects. Passive immunization has been suggested to be a safer alternative to active Aβ immunization but there are reports of increased risk of microhemorrhages associated with its administration in aged β-amyloid precursor protein transgenic mice bearing abundant vascular amyloid deposition. In addition, the cost may be prohibitive for large-scale clinical use. Therefore, we are designing novel Aβ immunogens that encompass the B cell epitope of Aβ but lack the T cell-reactive sites. These immunogens induced the production of Aβ-specific antibodies in the absence of an Aβ-specific cellular immune response in wild-type mice and are being tested in β-amyloid precursor protein transgenic mice. These data together with published reports from several other groups suggest that a safe, active Aβ vaccine is a tenable goal.


Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: Immunotherapies and Related Strategies in Alzheimer’s ...

Published online: 2/22/2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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