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Vol. 21, No. 3, 2006
Issue release date: February 2006
Section title: Original Research Article
Dement Geriatr Cogn Disord 2006;21:144–147
(DOI:10.1159/000090674)

Neuropathologic Correlates of Apathy in Alzheimer’s Disease

Marshall G.A. · Fairbanks L.A. · Tekin S. · Vinters H.V. · Cummings J.L.
Departments of aNeurology, bPsychiatry and Biobehavioral Neuroscience and cPathology and Laboratory Medicine (Neuropathology), University of California at Los Angeles, Los Angeles, Calif., and dFlorham Park, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 8/23/2005
Published online: 2/6/2006

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Apathy is the most commonly observed behavioral disturbance in Alzheimer’s disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 8/23/2005
Published online: 2/6/2006

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

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