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Table of Contents
Vol. 9, No. 1, 2006
Issue release date: February 2006
Section title: Assurance
Community Genet 2006;9:55–61
(DOI:10.1159/000090694)

PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships

Krawczak M. · Nikolaus S. · von Eberstein H. · Croucher P.J.P. · El Mokhtari N.E. · Schreiber S.
aInstitute of Medical Informatics and Statistics, Departments of bGeneral Internal Medicine and cCardiology, dInstitute for Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany

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Article / Publication Details

First-Page Preview
Abstract of Assurance

Received: 6/10/2005
Published online: 2/17/2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

Objective: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. Design: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. Results: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. Conclusion: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.


Article / Publication Details

First-Page Preview
Abstract of Assurance

Received: 6/10/2005
Published online: 2/17/2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


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