Journal Mobile Options
Table of Contents
Vol. 113, No. 1-4, 2006
Issue release date: March 2006

Interactions between imprinting effects: summary and review

Cattanach B.M. · Beechey C.V. · Peters J.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Mice with uniparental disomies (uniparental duplications) for defined regions of certain chromosomes, or certain disomies, show a range of developmental abnormalities most of which affect growth. These defects can be attributed to incorrect dosages of maternal or paternal copies of imprinted genes lying within the regions involved. Combinations of certain partial disomies result in interactions between the imprinting effects that seemingly independently affect foetal and/or placental growth in different ways or modify neonatal and postnatal development. The findings are generally in accord with the ‘conflict hypothesis’ for the evolution of genomic imprinting but do not demonstrate common growth axes within which imprinted genes may interact. Instead, it would seem that any gene that favours embryonic/foetal development, at consequent cost to the mother, will have been subject to evolutionary selection for only paternal allele expression. Reciprocally, any gene that reduces embryonic/foetal growth to limit disadvantage to the mother will have been selected for only maternal allele expression. It is concluded that survival of the placenta is core to the evolution of imprinting.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Cattanach BM: Parental origin effects in mice. J Embryol Exp Morph 97 Supplement:137–150 (1986).
  2. Cattanach BM, Beechey CV: Genomic imprinting in the mouse: possible final analysis, in Reik W, Surani A (eds): Frontiers in Molecular Biology, vol 18 Genomic Imprinting, pp 118–145 (at IRL Press for Oxford University Press, Oxford 1997).
  3. Cattanach BM, Kirk M: Chromosome 11 parental source effect upon foetal growth in mice. Genet Res 45:220–221 (1985).
  4. Cattanach BM, Barr JA, Evans EP, Burtenshaw M, Beechey CV, et al: A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nat Genet 2:270–274 (1992).
  5. Cattanach BM, Beechey CV, Rasberry C, Jones J, Papworth D: Time of initiation and site of action of the mouse chromosome 11 imprinting effects. Genet Res 68:35–44 (1996).
  6. Cattanach BM, Peters J, Ball S, Rasberry C: Two imprinted gene mutations: three phenotypes. Hum Mol Genet 9:2263–2273 (2000).
  7. Cattanach BM, Beechey CV, Peters J: Interactions between imprinting effects in the mouse. Genetics 168:397–413 (2004).
  8. Charalambous M, Smith FM, Bennett WR, Crew TE, Mackenzie F, et al: Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci USA 100:8292–8297 (2003).
  9. Clapcott SJ, Peters J, Orban PC, Brambilla R, Graham, CF: Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation. Mamm Genome 14:495–505 (2003).
  10. Constância M, Dean W, Lopes S, Moore T, Kelsey G, et al: Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.Nat Genet 26:203–206 (2000).
  11. Constância M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, et al: Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417:945–948 (2002).
  12. Crawford JA, Mutchler KJ, Sullivan BE, Lanigan TM, Clark MS, et al: Neural expression of a novel alternatively spliced and polyadenylated GSα transcript. J Biol Chem 268:9879–9885 (1993).
  13. Filson AJ, Louvi A, Efstratiadis A, Robertson EJ: Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and reciprocally imprinted genes. Development 118:731–736 (1993).
  14. Hall J: Genomic imprinting: review and relevance to human diseases. Am J Hum Genet 46:857–873 (1990).
  15. Itier J-M, Tremp GL, Léonard J-F, Multon M-C, Ret G, et al: Imprinted gene in postnatal growth role. Nature 393:125–126 (1998).
  16. Kaneko-Ishino T, Kohda T, Ishino F: The regulation and biological significance of genomic imprinting in mammals. J Biochem (Tokyo) 133:699–711 (2003).
  17. Li L-L, Keverne EB, Aparicio SS, Ishino F, Barton SC, et al: Regulation of maternal behavior and offspring growth by paternally expressed Peg3. Science 284:330–333 (1999).
  18. Monk D, Smith R, Arnaud P, Preece MA, Stanier P, et al: Imprinted methylation profiles for proximal mouse Chromosomes 11 and 7 as revealed by methylation-sensitive representation difference analysis. Mamm Genome 14:805–816 (2003).
  19. Moore T, Haig D: Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet 7:45–49 (1991).
  20. Müller EE, Locatelli V, Cocchi D: Neuroendocrine control of growth hormone secretion. Physiol Rev 79:511–607 (1999).
  21. Pasolli HA, Huttner WB: Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system. Neurosci Lett 301:119–122 (2001).
  22. Pasolli HA, Klenke M, Kehlenbach RH, Wang Y, Huttner WB: Characterization of the Extra-large G Protein α-Subunit XLαs. J Biol Chem 275:33622–33632 (2000).
  23. Plass C, Shibata H, Kalcheva I, Mullins L, Kotelevtseva N, et al: Identification of Grf1 on mouse chromosome 9 by RLGS-M. Nat Genet 14:106–100 (1996).
  24. Reik W, Constância M, Fowden A, Anderson N, Dean W, Ferguson-Smith A, Tycko B, Sibley C: Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol 547:35–44 (2003).
  25. Ren J, Lee S, Pagliardini S, Gérard M, Stewart CL, et al: Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J Neurosci 23:1569–1573 (2003).
  26. Sandell LL, Guan X-J, Ingram R, Tilghman SM: Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta. Proc Natl Acad Sci USA 100:4622–4627 (2003).
  27. Searle AG, Beechey CV: Genome imprinting phenomena on mouse chromosome 7. Genet Res 56:237–244 (1990).
  28. Skinner JA, Cattanach BM, Peters J: The imprinted oedematous-small mutation on mouse chromosome 2 identified new roles for Gnas and Gnasxl in development. Genomics 80:373–375 (2002).
  29. Sunahara S, Nakamura K, Nakao K, Gondo Y, Nagata Y, et al: The oocyte-specific methylated region of the U2afbp-rs/U2af1-rs1 gene is dispensible for its imprinted methylation. Biochem Biophys Res Commun 268:590–595 (2000).
  30. Williamson CM, Schofield J, Dutton ER, Seymour A, Beechey CV, et al: Glomerular-specific imprinting of the mouse GSα gene; how does this relate to hormone resistance in Albright Heriditary Osteodystrophy? Genomics 36:280–287 (1996).
  31. Williamson CM, Ball ST, Nottinham WT, Skinner JA, Plagge A, et al: A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas. Nat Genet 36:894–899 (2004).
  32. Zumkeller W: The effect of insulin-like growth factors on brain myelination and their potential therapeutic application in myelination disorders. Eur J Paediat Neurol 1:91–101 (1997).


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50