Dement Geriatr Cogn Disord 2006;21:198–204

Functional Vitamin E Deficiency in ApoE4 Patients with Alzheimer’s Disease

Mas E.a-c · Dupuy A.M.a, b · Artero S.b · Portet F.b, c · Cristol J.P.a · Ritchie K.b · Touchon J.b, c
aDepartment of Biochemistry, Lapeyronie Hospital, bINSERM, Unit E361, Epidemiology of Neurodegenerative Pathologies of the Nervous System, cDepartment of Neurology, Gui de Chauliac Hospital, Montpellier, France
email Corresponding Author

 goto top of outline Key Words

  • Vitamin E
  • Apolipoprotein E
  • Alzheimer’s disease

 goto top of outline Abstract

Oxidative stress has been implicated in the development of Alzheimer’s disease (AD). Consequently, antioxidant therapies including Vitamin E (VitE) supplementation for both prevention and treatment of neurodegenerative diseases currently appears to be a promising avenue of research. The aim of the present study was to examine the relationship between AD and the ApoE phenotype, lipid parameters and VitE levels in a large cohort of elderly subjects. No absolute deficit was observed in plasma VitE levels. However in AD, ApoE4 is not associated with an increase in total cholesterol (TC) and VitE levels. Moreover, our results suggest that oxidative stress-induced injury and protection by VitE in AD are related to the ApoE phenotype. Our study strongly supports the hypothesis of an impairment of lipophilic antioxidant delivery to neuronal cells in AD leading to a tissular antioxidant deficiency which could facilitate oxidative stress.

Copyright © 2006 S. Karger AG, Basel

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 goto top of outline Author Contacts

J.P. Cristol
Department of Biochemistry, Hôpital Lapeyronie
191 Avenue du Doyen Gaston Giraud
FR–34295 Montpellier Cédex 5 (France)
Tel. +33 467 338 345, Fax +33 467 338 393, E-Mail

 goto top of outline Article Information

Accepted: September 28, 2005
Published online: January 11, 2006
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 2, Number of References : 62

 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 21, No. 3, Year 2006 (Cover Date: February 2006)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

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