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Table of Contents
Vol. 22, No. 5, 2005
Issue release date: February 2006
Dig Surg 2005;22:371–374
(DOI:10.1159/000090996)

Primary Squamous Cell Carcinoma of the Colon Associated with Hypercalcemia and Hyperleukocytosis

Report of a Case

Yitta S. · Liang M.K. · Berman R. · Carter J.J. · Yee H.T. · Marks J.L.
Department of Surgery, New York University School of Medicine, Bellevue Hospital Center, New York, N.Y., USA

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Abstract

Background/Aims: Squamous cell carcinoma of the colon is a rare entity. We report a case of a patient who presented with a perforated squamous cell carcinoma of the sigmoid colon. Results: A 45-year-old female presented with a 2-month history of worsening abdominal pain, bloody diarrhea, and vomiting. She underwent an exploratory laparotomy and was found to have keratinizing squamous cell carcinoma of the sigmoid colon that had perforated forming multiple abscess cavities. The postoperative course was complicated by hypercalcemia and persistent hyperleukocytosis, ultimately resulting in the patient’s death. Conclusions: We present the second reported case of squamous cell carcinoma of the colon associated with hypercalcemia and the first reported case of associated hyperleukocytosis.



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References

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    External Resources

  9. Eichenhorn MS, Van Slyck EJ: Marked mature neutrophilic leukocytosis: a leukemoid variant associated with malignancy. Am J Med Sci 1982;284:32–36.
  10. Copur S, Ledakis P, Novinski D, Mleczko KL, Frankforter S, Bolotn M, Fruehling RM, VanWie E, Norvell M, Muhvic J: Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. Clin Colorectal Cancer 2001;1:55–58.


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