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Background/Aims: Squamous cell carcinoma of the colon is a rare entity. We report a case of a patient who presented with a perforated squamous cell carcinoma of the sigmoid colon. Results: A 45-year-old female presented with a 2-month history of worsening abdominal pain, bloody diarrhea, and vomiting. She underwent an exploratory laparotomy and was found to have keratinizing squamous cell carcinoma of the sigmoid colon that had perforated forming multiple abscess cavities. The postoperative course was complicated by hypercalcemia and persistent hyperleukocytosis, ultimately resulting in the patient’s death. Conclusions: We present the second reported case of squamous cell carcinoma of the colon associated with hypercalcemia and the first reported case of associated hyperleukocytosis.
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- Juturi JV, Francis B, Koontz PW, Wilkes JD: Squamous cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature. Dis Colon Rectum 1999;42:102–109.
- Yoshida J, Tohma, H, Nagata T, Okuzono Y, Takahashi M: Squamous cell carcinoma of the splenic flexure of the colon: report of a case. Jpn J Surg 1994;24:75–79.
- Crissman JD: Adenosquamous and squamous cell carcinoma of the colon. Am J Surg Pathol 1978;2:47–54.
- Frizelle FA, Hobday KS, Batts KP, Nelson H: Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study. Dis Colon Rectum 2001;44:341–346.
- Audeau A, Han HW, Johnston MJ, Whitehead MW, Frizelle FA: Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum? Eur J Surg Oncol 2002;6:657–660.
- Delellis RA, Xia L: Paraneoplastic andocrine syndromes: a review. Endocr Pathol 2003;14:303–318.
- Thompson JT, Paschold EH, Levine EA: Paraneoplastic hypercalcemia in a patient with adenosquamous cancer of the colon. Am Surg 2001;67:585–588.
- Clifford ML: Excess leukocytosis (leukemoid reactions) associated with malignant diseases. South Med J 1985;78:1475–1482.
- Eichenhorn MS, Van Slyck EJ: Marked mature neutrophilic leukocytosis: a leukemoid variant associated with malignancy. Am J Med Sci 1982;284:32–36.
- Copur S, Ledakis P, Novinski D, Mleczko KL, Frankforter S, Bolotn M, Fruehling RM, VanWie E, Norvell M, Muhvic J: Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. Clin Colorectal Cancer 2001;1:55–58.