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Vol. 24, No. 1-2, 2006
Issue release date: May 2006
Section title: Original Paper
Dig Dis 2006;24:201–206
(DOI:10.1159/000091299)

Infliximab Therapy Improves the Bone Metabolism in Fistulizing Crohn’s Disease

Miheller P. · Müzes G. · Zagoni T. · Toth M. · Racz K. · Tulassay Z.
aSemmelweis University, Second Department of Internal Medicine, and bHungarian Academy of Sciences, Gastroenterological and Endocrinological Research Group, Budapest, Hungary

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/12/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI

Abstract

Background: Tumor necrosis factor-α (TNF-α) plays a pivotal role in the pathogenesis of inflammatory bowel diseases and bone resorption as well. Limited data exist about the effect of anti-TNF-α infliximab on bone metabolism in inflammatory-type Crohn’s disease (CD). Aim: Our aim was to evaluate the effect of infliximab treatment on rapid changes of bone metabolism in fistulizing CD patients. Methods: 27 patients with fistulizing CD were treated with three series of infliximab. Serum osteocalcin (OC) and β-CrossLaps (bCL) were measured before administration of each infliximab infusion. 54 patients with inactive CD were controls. Results: In treated patients, there were significant differences in bCL concentrations on days 0 and 14 (p < 0.01) and days 0 and 42 (p < 0.05). OC levels increased significantly between day 0 and 42 (p < 0.05). The values of bCL and OC of control groups differed from serum levels in active patients before the treatment, but not on day 42. Bone markers improved significantly in responder patients, but not in non-responders. Conclusion: The beneficial effect of infliximab to the bone metabolism is more expressive in patients whose fistulizing disease improves with this therapy. Our results suggest that TNF-α has an important role in the alteration of bone metabolism in fistulizing CD patients.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 5/12/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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