Journal Mobile Options
Table of Contents
Vol. 90, No. 2, 2006
Issue release date: August 2006
Section title: Original Paper
Biol Neonate 2006;90:89–97
(DOI:10.1159/000092005)

Hyperoxia and Tidal Volume: Independent and Combined Effects on Neonatal Pulmonary Inflammation

Ehlert C.A. · Truog W.E. · Thibeault D.W. · Garg U. · Norberg M. · Rezaiekhaligh M. · Mabry S. · Ekekezie I.I.
aSection of Neonatal-Perinatal Medicine, bSection of Pathology, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Mo., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/2005
Accepted: 10/24/2005
Published online: 8/10/2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. Objectives: To study the independent and combined effects of hyperoxia and tidal volume mechanical ventilation on the induction of lung inflammation in a newborn piglet model of ventilator-induced lung injury. Methods: Following exposure to either ambient air or FIO2 = 1.0 for a period of 3 days, newborn piglets were randomized to receive mechanical ventilation with either high tidal volume (20 ml/kg) or low tidal volume (6 ml/kg) for 4 h while controlling for pH. Results: Monocyte chemoattractant protein-1 level in the lungs of animals randomized to hyperoxia with high tidal volume ventilation was significantly elevated, compared to all other groups (p < 0.05). Myeloperoxidase assayed in lung homogenate was found to be significantly higher in nonventilated animals exposed to hyperoxia (p < 0.01). Only in animals previously exposed to hyperoxia did the addition of high tidal volume ventilation further increase the level of myeloperoxidase present (p < 0.05). Pulmonary vascular resistance was significantly elevated after 4 h of mechanical ventilation compared to 1 h (p < 0.001). Conclusions: We conclude that in neonatal piglets undergoing hyperoxic stress, superimposition of high tidal volume ventilation exacerbates the lung inflammation as assessed by lung monocyte chemoattractant protein-1 and level of myeloperoxidase.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/2005
Accepted: 10/24/2005
Published online: 8/10/2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Strieter RM, Kunkel SL, Keane MP, Standiford TJ: Chemokines in lung injury: Thomas A. Neff Lecture. Chest 1999;116:103S–110S.
  2. Dos Santos CC, Slutsky AS: Cellular responses to mechanical stress. Invited review: mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol2000;89:1645–1655.
  3. Speer CP, Groneck P: Oxygen radicals, cytokines, adhesion molecules and lung injury in neonates. Semin Neonatol1998;3:219–228.

    External Resources

  4. Ekekezie II, Thibeault DW, Rezaiekhaligh MH, Mabry SM, Norberg M, Reddy GK, Youssef J, Truog WE: High-dose inhaled nitric oxide and hyperoxia increases lung collagen accumulation in piglets. Biol Neonate 2000;78:198–206.
  5. Shaffer SG, O’Neill D, Bradt SK, Thibeault DW: Chronic vascular pulmonary dysplasia associated with neonatal hyperoxia exposure in the rat. Pediatr Res 1987;21:14–20.
  6. Fox RB, Hoidal JR, Brown DM, Repine JE: Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes. Am Rev Respir Dis 1981;123:521–523.
  7. Ekekezie II, Thibeault DW, Zwick DL, Rezaiekhaligh MH, Mabry SM, Morgan RE, Norberg M, Truog WE: Independent and combined effects of prolonged inhaled nitric oxide and oxygen on lung inflammation in newborn piglets. Biol Neonate 2000;77:37–44.
  8. Ben-Ari J, Makhoul IR, Dorio RJ, Buckley S, Warburton D, Walker SM: Cytokine response during hyperoxia: sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats. Isr Med Assoc J 2000;2:365–369.
  9. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998;338:347–354.
  10. Corbridge TC, Wood LD, Crawford GP, Chudoba MJ, Yanos J, Sznajder JI: Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis 1990;142:311–315.
  11. Dreyfuss D, Soler P, Basset G, Saumon G: High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159–1164.
  12. Peevy KJ, Hernandez LA, Moise AA, Parker JC: Barotrauma and microvascular injury in lungs of nonadult rabbits: effect of ventilation pattern. Crit Care Med 1990;18:634–637.
  13. Tsuno K, Prato P, Kolobow T: Acute lung injury from mechanical ventilation at moderately high airway pressures. J Appl Physiolol 1990;69:956–961.
  14. Muscedere JG, Mullen JB, Gan K, Slutsky AS: Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 1994;149:1327–1334.
  15. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS: Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 1999;282:54–61.
  16. International Consensus Conferences Committee: International consensus conferences in intensive care medicine: ventilator-associated lung injury in ARDS. Am J Respir Crit Care Med 1999;160:2118–2124.

    External Resources

  17. Chiumello D, Pristine G, Slutsky AS: Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:109–116.
  18. Held HD, Boettcher S, Hamann L, Uhlig S: Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappa B and is blocked by steroids. Am J Respir Crit Care Med 2001;163:711–716.
  19. Ricard JD, Dreyfuss D, Saumon G: Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med 2001;163:1176–1180.
  20. Ehlert CA, Ekekezie II, Thibeault DW, Norberg M, Rezaiekhaligh M, Mabry S, Truog WE: Hyperoxia and tidal volume: independent and combined effects on neonatal pulmonary inflammation. Pediatr Res 2002;51:336A.
  21. Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH: Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997;41:457–463.
  22. Krawisz JE, Sharon P, Stenson WF: Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984;87:1344–1350.
  23. Foda HD, Rollo EE, Drews M, Conner C, Appelt K, Shalinsky DR, Zucker S: Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340). Am J Respir Cell Mol Biol 2001;25:717–724.
  24. Ekekezie II, Thibeault DW, Garola RE, Truog WE: Monocyte chemoattractant protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric oxide and hyperoxia. Pediatr Res 2001;50:633–640.
  25. Davis JM, Penney DP, Notter RH, Metlay L, Dickerson B, Shapiro DL: Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation. J Appl Physiol 1989;67:1007–1012.
  26. Davis JM, Dickerson B, Metlay L, Penney DP: Differential effects of oxygen and barotrauma on lung injury in the neonatal piglet. Pediatr Pulmonol 1991;10:157–163.
  27. Dreyfuss D, Ricard JD, Saumon G: On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury. Am J Respir Crit Care Med 2003;167:1467–1471.
  28. Copland IB, Martinez F, Kavanagh BP, Engelberts D, McKerlie C, Belik J, Post M: High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med 2004;169:739–748.
  29. Tobin MJ: Culmination of an era in research on the acute respiratory distress syndrome. N Engl J Med 2000;342:1360–1361.
  30. Berg JT, Fu Z, Breen EC, Tran HC, Mathieu-Costello O, West JB: High lung inflation increases mRNA levels of ECM components and growth factors in lung parenchyma. J Appl Physiol 1997;83:120–128.