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Vol. 19, No. 4, 2006
Issue release date: July 2006
Skin Pharmacol Appl Skin Physiol 2006;19:224–231

Antioxidant Supplements Improve Parameters Related to Skin Structure in Humans

Heinrich U. · Tronnier H. · Stahl W. · Béjot M. · Maurette J.-M.
aInstitute of Experimental Dermatology, University of Witten/Herdecke, Witten, bInstitute of Biochemistry and Molecular Biology I, University of Düsseldorf, Düsseldorf, Germany, and cLaboratoire Oenobiol, Paris, France

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In the present study we investigated the influence of two different antioxidant supplements composed of carotenoids, vitamin E and selenium on parameters related to skin health and skin aging. Thirty-nine volunteers with healthy, normal skin of skin type 2 were divided into 3 groups (n = 13) and supplemented for a period of 12 weeks. Group 1 received a mixture of lycopene (3 mg/day), lutein (3 mg/day), β-carotene (4.8 mg/day), α-tocopherol (10 mg/day) and selenium (75 µg/day). Group 2 was supplemented with a mixture of lycopene (6 mg/day), β-carotene (4.8 mg/day), α-tocopherol (10 mg/day) and selenium (75 µg/day). Group 3 was the placebo control. Upon supplementation serum levels of selected carotenoids increased in both verum groups. Skin density and thickness were determined by ultrasound measurements. A significant increase for both parameters was determined in the verum groups. Roughness, scaling, smoothness and wrinkling of the skin were determined by Surface Evaluation of Living Skin (Visioscan). Roughness and scaling were improved by the supplementation with antioxidant micronutrients. In the placebo group no changes were found for any of the parameters.

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